Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 2628306..2628859 Replicon chromosome
Accession NZ_CP116477
Organism Pectobacterium sp. A5351

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag O1Q74_RS12295 Protein ID WP_029729595.1
Coordinates 2628306..2628620 (-) Length 105 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID A0A3S1FM98
Locus tag O1Q74_RS12300 Protein ID WP_029729596.1
Coordinates 2628623..2628859 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1Q74_RS12260 (O1Q74_12260) 2623484..2624734 + 1251 WP_271873521.1 integrase domain-containing protein -
O1Q74_RS12265 (O1Q74_12265) 2625001..2625216 + 216 WP_224717866.1 AlpA family phage regulatory protein -
O1Q74_RS12270 (O1Q74_12270) 2625356..2625547 - 192 WP_014915000.1 YlcI/YnfO family protein -
O1Q74_RS12275 (O1Q74_12275) 2625612..2626094 + 483 WP_271873526.1 transposase -
O1Q74_RS12280 (O1Q74_12280) 2626130..2626423 + 294 WP_271873528.1 helix-turn-helix domain-containing protein -
O1Q74_RS12285 (O1Q74_12285) 2626468..2627618 + 1151 Protein_2378 IS3 family transposase -
O1Q74_RS12290 (O1Q74_12290) 2627636..2627860 + 225 WP_271873529.1 DUF4326 domain-containing protein -
O1Q74_RS12295 (O1Q74_12295) 2628306..2628620 - 315 WP_029729595.1 CcdB family protein Toxin
O1Q74_RS12300 (O1Q74_12300) 2628623..2628859 - 237 WP_029729596.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
O1Q74_RS12305 (O1Q74_12305) 2629178..2630122 - 945 WP_271873530.1 zincin-like metallopeptidase domain-containing protein -
O1Q74_RS12310 (O1Q74_12310) 2630708..2632411 - 1704 WP_271873531.1 DUF2326 domain-containing protein -
O1Q74_RS12315 (O1Q74_12315) 2632638..2633228 - 591 WP_271873532.1 hypothetical protein -
O1Q74_RS12320 (O1Q74_12320) 2633221..2633472 - 252 WP_271873533.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-103)

Antitoxin

Post-segregation antitoxin CcdA

(9-78)


Sequences

Toxin        


Download         Length: 105 a.a.        Molecular weight: 11591.54 Da        Isoelectric Point: 7.9874

>T268724 WP_029729595.1 NZ_CP116477:c2628620-2628306 [Pectobacterium sp. A5351]
MQFTVYGNTGKSVVYPLLLDVTSDIIGQLNRRIVIPLLPIERYPAGRRPERLVPVVRLTDGKEYAVMTHELASIPVQALG
AVFCDASQYRTQIKAAIDFLIDGF

Download         Length: 315 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8927.96 Da        Isoelectric Point: 6.4612

>AT268724 WP_029729596.1 NZ_CP116477:c2628859-2628623 [Pectobacterium sp. A5351]
MTAKQRNTQSVTMTVERALLVRAREAGINLSATLTTALDAELRSHEAKKWQEENREALAALNRFHDEQGCFSDEYRTF

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A3S1FM98

References