Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 405425..407069 Replicon chromosome
Accession NZ_CP116477
Organism Pectobacterium sp. A5351

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag O1Q74_RS01920 Protein ID WP_271875859.1
Coordinates 405735..407069 (+) Length 445 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID C6CLK4
Locus tag O1Q74_RS01915 Protein ID WP_015848020.1
Coordinates 405425..405730 (+) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
O1Q74_RS01890 (O1Q74_01890) 400954..402069 + 1116 WP_271875856.1 LPS export ABC transporter permease LptF -
O1Q74_RS01895 (O1Q74_01895) 402069..403145 + 1077 WP_010284634.1 LPS export ABC transporter permease LptG -
O1Q74_RS01905 (O1Q74_01905) 403682..404938 + 1257 WP_271875857.1 tyrosine-type recombinase/integrase -
O1Q74_RS01910 (O1Q74_01910) 404957..405118 + 162 WP_271875858.1 CopG family transcriptional regulator -
O1Q74_RS01915 (O1Q74_01915) 405425..405730 + 306 WP_015848020.1 helix-turn-helix transcriptional regulator Antitoxin
O1Q74_RS01920 (O1Q74_01920) 405735..407069 + 1335 WP_271875859.1 type II toxin-antitoxin system HipA family toxin Toxin
O1Q74_RS01925 (O1Q74_01925) 407345..408433 - 1089 WP_271878704.1 helicase RepA family protein -
O1Q74_RS01930 (O1Q74_01930) 408545..409381 - 837 Protein_357 primase-helicase zinc-binding domain-containing protein -
O1Q74_RS01935 (O1Q74_01935) 409374..409910 - 537 WP_271875860.1 ash family protein -
O1Q74_RS01940 (O1Q74_01940) 409907..410107 - 201 WP_271875861.1 AlpA family transcriptional regulator -
O1Q74_RS01945 (O1Q74_01945) 410110..410988 - 879 WP_271875862.1 integrase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(155-406)

Antitoxin

Cro/C1-type helix-turn-helix domain

(20-68)


Sequences

Toxin        


Download         Length: 445 a.a.        Molecular weight: 50926.97 Da        Isoelectric Point: 5.8437

>T268717 WP_271875859.1 NZ_CP116477:405735-407069 [Pectobacterium sp. A5351]
MPRTQQRLAIWMNGIQVGFWEKTRGEDRLQYLPEWIADEQGRPLSLSLLFTPGNQLWRGNVVRDYFDNLLPDSEGIRRRL
ATRYHADSLEPFDLLAELGRDCVGAIQLLNGNEEPTDLFSVNYRPLCEAEIATILRNTTAALLPGRQDDTDDLRLSIAGA
QEKTALLWHERQWCLPEGSTPTTHIFKLPLGLVGNMQADMSTSVENEWLCSLILKEYGIPVAKTQIAQFEDQKVLVVERF
DRRWSSDQQWIIRLPQEDMCQALGVSPLRKYQSDGGPGISDIMTILSHSEQAEQDKAQFFRAQIIFWLIAATDGHAKNFS
ITIEPQGRYHLTPLYDVLSAWPVIGPRNNQISWQKCKLAMAVRGSSNYYHLYRIQRRHWVNHGELTGLGRRQVEAMMDDI
ISRTPEVIERVSSLLPESFPPELAECVFDGMRQQCGRLQELHRK

Download         Length: 1335 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 11313.11 Da        Isoelectric Point: 10.5325

>AT268717 WP_015848020.1 NZ_CP116477:405425-405730 [Pectobacterium sp. A5351]
MNTVYPLKTLNQLRPLLIGFRKAKGLTQKDVSERLGVTQQTYARLEANPGSASIERLFKVLTVLGVEVVLSSGPRVHFSM
SSSTMEEPEKPIDSPARREKW

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1V2R984

References