Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 1326274..1326938 Replicon chromosome
Accession NZ_CP116458
Organism Acidithiobacillus ferriphilus strain YL25

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PJU76_RS06615 Protein ID WP_271780974.1
Coordinates 1326507..1326938 (+) Length 144 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PJU76_RS06610 Protein ID WP_271780973.1
Coordinates 1326274..1326507 (+) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PJU76_RS06595 (PJU76_06595) 1323663..1325132 + 1470 WP_271780970.1 DNA-3-methyladenine glycosylase 2 -
PJU76_RS06600 (PJU76_06600) 1325129..1325653 - 525 WP_271780971.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
PJU76_RS06605 (PJU76_06605) 1325748..1326032 - 285 WP_271780972.1 hypothetical protein -
PJU76_RS06610 (PJU76_06610) 1326274..1326507 + 234 WP_271780973.1 CopG family transcriptional regulator Antitoxin
PJU76_RS06615 (PJU76_06615) 1326507..1326938 + 432 WP_271780974.1 VapC toxin family PIN domain ribonuclease Toxin
PJU76_RS06620 (PJU76_06620) 1327284..1327535 - 252 WP_271780975.1 hypothetical protein -
PJU76_RS06625 (PJU76_06625) 1327557..1327763 + 207 WP_271780976.1 hypothetical protein -
PJU76_RS06630 (PJU76_06630) 1327821..1328072 + 252 WP_271780977.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
PJU76_RS06635 (PJU76_06635) 1328087..1328449 + 363 WP_271780978.1 type II toxin-antitoxin system PemK/MazF family toxin -
PJU76_RS06640 (PJU76_06640) 1328608..1328994 + 387 WP_271780979.1 hypothetical protein -
PJU76_RS06645 (PJU76_06645) 1329136..1329351 + 216 WP_271780980.1 DUF4926 domain-containing protein -
PJU76_RS06650 (PJU76_06650) 1329612..1330130 + 519 WP_271780981.1 DinB family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-127)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 144 a.a.        Molecular weight: 15685.05 Da        Isoelectric Point: 6.5750

>T268709 WP_271780974.1 NZ_CP116458:1326507-1326938 [Acidithiobacillus ferriphilus]
MIFLLDVNVLIALIDPMHVQHDMAHEWFAAHGQPAWATCPLTENGVLRIVSHPRYPNSPGTPAAVAPLIQGLRASPGHVF
WPDDISLLDVDHIDASRLLTSGQITNSYLLALACAHEGQLATFDHRLVTNAVRNSLQCINKIK

Download         Length: 432 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8162.32 Da        Isoelectric Point: 7.2027

>AT268709 WP_271780973.1 NZ_CP116458:1326274-1326507 [Acidithiobacillus ferriphilus]
MRTTLAIDDDVLAAAKGLADRQHKPVGAVVSALLRQALQSQNTSGGHSRNGIPLLSVRPDALPATLEIVNQLRDELP

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References