Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 218189..218817 Replicon chromosome
Accession NZ_CP116458
Organism Acidithiobacillus ferriphilus strain YL25

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PJU76_RS01035 Protein ID WP_271780106.1
Coordinates 218416..218817 (+) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag PJU76_RS01030 Protein ID WP_271780105.1
Coordinates 218189..218419 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PJU76_RS01005 (PJU76_01005) 214144..214506 + 363 WP_271780101.1 response regulator -
PJU76_RS01010 (PJU76_01010) 214524..215600 + 1077 WP_271780102.1 response regulator -
PJU76_RS01015 (PJU76_01015) 215613..215813 - 201 WP_215849469.1 hypothetical protein -
PJU76_RS01020 (PJU76_01020) 215824..217194 - 1371 WP_271780103.1 divalent metal cation transporter -
PJU76_RS01025 (PJU76_01025) 217386..217964 + 579 WP_271780104.1 DUF4337 domain-containing protein -
PJU76_RS01030 (PJU76_01030) 218189..218419 + 231 WP_271780105.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
PJU76_RS01035 (PJU76_01035) 218416..218817 + 402 WP_271780106.1 tRNA(fMet)-specific endonuclease VapC Toxin
PJU76_RS01040 (PJU76_01040) 218993..219523 + 531 WP_271780107.1 DedA family protein -
PJU76_RS01050 (PJU76_01050) 220263..221042 - 780 WP_271780108.1 ABC transporter permease -
PJU76_RS01055 (PJU76_01055) 221039..221980 - 942 WP_271780109.1 ATP-binding cassette domain-containing protein -
PJU76_RS01060 (PJU76_01060) 221949..222674 - 726 WP_271780110.1 CocE/NonD family hydrolase -
PJU76_RS01065 (PJU76_01065) 222674..222964 - 291 WP_271780111.1 (2Fe-2S) ferredoxin domain-containing protein -
PJU76_RS01070 (PJU76_01070) 223064..223690 + 627 WP_271780112.1 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(8-50)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15008.43 Da        Isoelectric Point: 9.0203

>T268705 WP_271780106.1 NZ_CP116458:218416-218817 [Acidithiobacillus ferriphilus]
VINYLLDTNICIFTIKCKPPEIREQFRRYHGQMAISAVTLMELIYGAEKSQAPERNLAEIEGFAARLELLEYGSEAAKHT
GQIRAELAKVGKPIGPYDQMIAGHARSRGLIVVTNNLRKFERVPGLRVVDWVQ

Download         Length: 402 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8575.80 Da        Isoelectric Point: 5.0644

>AT268705 WP_271780105.1 NZ_CP116458:218189-218419 [Acidithiobacillus ferriphilus]
MEKATIFLSNRSQAVRLPKAIAFPADVKRVEVLVMGRARMLIPAGESWDSWFDGEGVSADFMEHREQPADQVRESL

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References