Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yoeB-relB/YoeB-YefM
Location 50221..50723 Replicon chromosome
Accession NZ_CP116458
Organism Acidithiobacillus ferriphilus strain YL25

Toxin (Protein)


Gene name yoeB Uniprot ID A0A1B9BYX7
Locus tag PJU76_RS00240 Protein ID WP_065413237.1
Coordinates 50469..50723 (+) Length 85 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A060ULQ1
Locus tag PJU76_RS00235 Protein ID WP_035191769.1
Coordinates 50221..50472 (+) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PJU76_RS00215 (PJU76_00215) 45602..46198 + 597 WP_215860337.1 glycerol-3-phosphate 1-O-acyltransferase PlsY -
PJU76_RS00220 (PJU76_00220) 46227..47240 - 1014 WP_271779974.1 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex transferase subunit TsaD -
PJU76_RS00225 (PJU76_00225) 47237..48070 - 834 WP_271779975.1 ferritin-like domain-containing protein -
PJU76_RS00230 (PJU76_00230) 48196..49707 - 1512 WP_271779976.1 PQQ-binding-like beta-propeller repeat protein -
PJU76_RS00235 (PJU76_00235) 50221..50472 + 252 WP_035191769.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PJU76_RS00240 (PJU76_00240) 50469..50723 + 255 WP_065413237.1 Txe/YoeB family addiction module toxin Toxin
PJU76_RS00245 (PJU76_00245) 50911..51156 + 246 WP_271779977.1 Arc family DNA-binding protein -
PJU76_RS00250 (PJU76_00250) 51153..51548 + 396 WP_271779978.1 type II toxin-antitoxin system VapC family toxin -
PJU76_RS00255 (PJU76_00255) 51763..52638 - 876 WP_271779979.1 restriction endonuclease -
PJU76_RS00260 (PJU76_00260) 52762..53664 - 903 WP_271779980.1 hypothetical protein -
PJU76_RS00265 (PJU76_00265) 53753..54397 - 645 WP_271779981.1 LysE family translocator -
PJU76_RS00270 (PJU76_00270) 54497..55009 - 513 WP_271779982.1 hypothetical protein -
PJU76_RS00275 (PJU76_00275) 55108..55329 - 222 WP_064217696.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 85 a.a.        Molecular weight: 10226.74 Da        Isoelectric Point: 9.4809

>T268704 WP_065413237.1 NZ_CP116458:50469-50723 [Acidithiobacillus ferriphilus]
VRLIFSDDAWEDYLYWQKQDKRMVERINKLIRETQREPFAGVGKPEALKHALSGFWSRRITDEHRMVYRIEGDALMIAQL
RFHY

Download         Length: 255 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9118.51 Da        Isoelectric Point: 6.9767

>AT268704 WP_035191769.1 NZ_CP116458:50221-50472 [Acidithiobacillus ferriphilus]
MDAITYTTVRANLASAMDRVCDDHEPLIITRNGEQSVVMLSLEDYKALEETAYLLRTPANAKRLLAAVAQLNAGKGVERK
LAK

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1B9BYX7

Antitoxin

Source ID Structure
AlphaFold DB A0A060ULQ1

References