Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/RelB(antitoxin)
Location 1617646..1618258 Replicon chromosome
Accession NZ_CP116457
Organism Streptococcus pyogenes strain 1095

Toxin (Protein)


Gene name parE Uniprot ID Q5X9X8
Locus tag PJV85_RS07965 Protein ID WP_011018227.1
Coordinates 1617923..1618258 (+) Length 112 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID Q5X9X9
Locus tag PJV85_RS07960 Protein ID WP_002988079.1
Coordinates 1617646..1617933 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PJV85_RS07935 (PJV85_07935) 1612823..1613806 - 984 WP_002982755.1 tagatose-bisphosphate aldolase -
PJV85_RS07940 (PJV85_07940) 1613810..1614739 - 930 WP_010922663.1 tagatose-6-phosphate kinase -
PJV85_RS07945 (PJV85_07945) 1614787..1615302 - 516 WP_002988082.1 galactose-6-phosphate isomerase subunit LacB -
PJV85_RS07950 (PJV85_07950) 1615337..1615765 - 429 WP_010922664.1 galactose-6-phosphate isomerase subunit LacA -
PJV85_RS07955 (PJV85_07955) 1616212..1616985 + 774 WP_002982738.1 DeoR/GlpR family DNA-binding transcription regulator -
PJV85_RS07960 (PJV85_07960) 1617646..1617933 + 288 WP_002988079.1 DNA-damage-inducible protein J Antitoxin
PJV85_RS07965 (PJV85_07965) 1617923..1618258 + 336 WP_011018227.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PJV85_RS07970 (PJV85_07970) 1618356..1619363 + 1008 Protein_1510 site-specific integrase -
PJV85_RS07975 (PJV85_07975) 1619483..1619875 - 393 WP_002982716.1 30S ribosomal protein S9 -
PJV85_RS07980 (PJV85_07980) 1619896..1620342 - 447 WP_002982710.1 50S ribosomal protein L13 -
PJV85_RS07985 (PJV85_07985) 1620560..1620766 - 207 WP_002982695.1 helix-turn-helix transcriptional regulator -
PJV85_RS07990 (PJV85_07990) 1620763..1621269 - 507 WP_002988070.1 hypothetical protein -
PJV85_RS07995 (PJV85_07995) 1621405..1622265 - 861 WP_002982687.1 DegV family protein -
PJV85_RS08000 (PJV85_08000) 1622362..1622880 - 519 WP_002982682.1 NYN domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(8-105)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 112 a.a.        Molecular weight: 13171.97 Da        Isoelectric Point: 5.2144

>T268703 WP_011018227.1 NZ_CP116457:1617923-1618258 [Streptococcus pyogenes]
MDYKKYQIIYAPDVLEKLKEIRDYISQNYSSTSGQRKMEQIISDIEKLEVFPEVGFDADEKYGSKIIHYHSTKGYTLSKD
YIVLYHIEGEENRVVIDYLLPTQSDYIKLFK

Download         Length: 336 bp

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10934.56 Da        Isoelectric Point: 5.2318

>AT268703 WP_002988079.1 NZ_CP116457:1617646-1617933 [Streptococcus pyogenes]
MTTVKKNRAVTFQANKELVSEAMTVLNKKNLTLSSALRLFLQNVVVTNEVDLLTEEELEKEKLFKQFQAEINKNIEDVRQ
GKFYTSEEVRAELGL

Download         Length: 288 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7Z2QKE7

Antitoxin

Source ID Structure
AlphaFold DB A0A4U7GX94

References