268695

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4363102..4363599 Replicon chromosome
Accession NZ_CP116411
Organism Escherichia coli strain HH45

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag PL330_RS20785 Protein ID WP_001173343.1
Coordinates 4363102..4363275 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag PL330_RS20790 Protein ID WP_000398619.1
Coordinates 4363303..4363599 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL330_RS20775 (4359772) 4359772..4361229 + 1458 WP_000856834.1 dipeptide/tripeptide permease DtpC -
PL330_RS20780 (4361466) 4361466..4362983 + 1518 WP_001295074.1 lysine--tRNA ligase -
PL330_RS20785 (4363102) 4363102..4363275 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
PL330_RS20790 (4363303) 4363303..4363599 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
PL330_RS20795 (4363826) 4363826..4364098 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
PL330_RS20800 (4364110) 4364110..4364340 - 231 WP_000371700.1 4Fe-4S mono-cluster protein YjdI -
PL330_RS20805 (4364521) 4364521..4366152 + 1632 WP_001216460.1 sensor histidine kinase -
PL330_RS20810 (4366149) 4366149..4366868 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T268695 WP_001173343.1 NZ_CP116411:c4363275-4363102 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT268695 WP_000398619.1 NZ_CP116411:c4363599-4363303 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References