268692

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3545001..3545619 Replicon chromosome
Accession NZ_CP116411
Organism Escherichia coli strain HH45

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PL330_RS16985 Protein ID WP_001291435.1
Coordinates 3545401..3545619 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PL330_RS16980 Protein ID WP_000344800.1
Coordinates 3545001..3545375 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL330_RS16970 (3540090) 3540090..3541283 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PL330_RS16975 (3541306) 3541306..3544455 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PL330_RS16980 (3545001) 3545001..3545375 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PL330_RS16985 (3545401) 3545401..3545619 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PL330_RS16990 (3545791) 3545791..3546342 + 552 WP_000102568.1 maltose O-acetyltransferase -
PL330_RS16995 (3546458) 3546458..3546928 + 471 WP_000136192.1 YlaC family protein -
PL330_RS17000 (3547092) 3547092..3548642 + 1551 WP_001299455.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PL330_RS17005 (3548684) 3548684..3549037 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PL330_RS17015 (3549416) 3549416..3549727 + 312 WP_000409911.1 MGMT family protein -
PL330_RS17020 (3549758) 3549758..3550330 - 573 WP_000779826.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T268692 WP_001291435.1 NZ_CP116411:3545401-3545619 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT268692 WP_000344800.1 NZ_CP116411:3545001-3545375 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References