Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2412146..2413734 Replicon chromosome
Accession NZ_CP116411
Organism Escherichia coli strain HH45

Toxin (Protein)


Gene name hipA Uniprot ID A0A6D2FBH6
Locus tag PL330_RS11505 Protein ID WP_001125470.1
Coordinates 2412412..2413734 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PL330_RS11500 Protein ID WP_001296726.1
Coordinates 2412146..2412412 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL330_RS11480 (2408504) 2408504..2409955 + 1452 WP_000854624.1 tagaturonate reductase -
PL330_RS11485 (2410162) 2410162..2411076 + 915 WP_000637082.1 bestrophin family protein -
PL330_RS11490 (2411080) 2411080..2411838 - 759 WP_001286565.1 trans-aconitate 2-methyltransferase -
PL330_RS11495 (2411895) 2411895..2411957 - 63 Protein_2249 autoinducer-2 (AI-2) modifying protein LsrG -
PL330_RS11500 (2412146) 2412146..2412412 + 267 WP_001296726.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PL330_RS11505 (2412412) 2412412..2413734 + 1323 WP_001125470.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
PL330_RS11510 (2414046) 2414046..2414254 + 209 Protein_2252 AraC family transcriptional regulator -
PL330_RS11515 (2414686) 2414686..2415249 + 564 WP_001296758.1 type 1 fimbrial major subunit FimA -
PL330_RS11520 (2415610) 2415610..2416320 + 711 WP_001195166.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimA 2388591..2429499 40908


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-102)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49323.86 Da        Isoelectric Point: 8.8783

>T268691 WP_001125470.1 NZ_CP116411:2412412-2413734 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTSLPENETITRPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALRDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10047.39 Da        Isoelectric Point: 4.9632

>AT268691 WP_001296726.1 NZ_CP116411:2412146-2412412 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6D2FBH6

Antitoxin

Source ID Structure

References