268684

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 928568..929222 Replicon chromosome
Accession NZ_CP116411
Organism Escherichia coli strain HH45

Toxin (Protein)


Gene name cptA Uniprot ID F4NJ21
Locus tag PL330_RS04510 Protein ID WP_000244772.1
Coordinates 928815..929222 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PL330_RS04505 Protein ID WP_000354046.1
Coordinates 928568..928834 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL330_RS04485 (924656) 924656..926089 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
PL330_RS04490 (926134) 926134..926445 + 312 WP_001182944.1 N(4)-acetylcytidine aminohydrolase -
PL330_RS04495 (926609) 926609..927268 + 660 WP_000250274.1 hemolysin III family protein -
PL330_RS04500 (927345) 927345..928325 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
PL330_RS04505 (928568) 928568..928834 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PL330_RS04510 (928815) 928815..929222 + 408 WP_000244772.1 protein YgfX Toxin
PL330_RS04515 (929262) 929262..929783 - 522 WP_001055874.1 flavodoxin FldB -
PL330_RS04520 (929895) 929895..930791 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PL330_RS04525 (930816) 930816..931526 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PL330_RS04530 (931532) 931532..933265 + 1734 WP_000813215.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16048.02 Da        Isoelectric Point: 11.2511

>T268684 WP_000244772.1 NZ_CP116411:928815-929222 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWCIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT268684 WP_000354046.1 NZ_CP116411:928568-928834 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0E0XYB4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QD57

References