Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) yjhX-yjhQ/YjhX-GNAT
Location 4439648..4440462 Replicon chromosome
Accession NZ_CP116409
Organism Escherichia coli strain HH97

Toxin (Protein)


Gene name yjhX Uniprot ID S1PA82
Locus tag PL329_RS21685 Protein ID WP_001054376.1
Coordinates 4439648..4439905 (+) Length 86 a.a.

Antitoxin (Protein)


Gene name yjhQ Uniprot ID U9Z4B8
Locus tag PL329_RS21690 Protein ID WP_001309181.1
Coordinates 4439917..4440462 (+) Length 182 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL329_RS21655 (4434804) 4434804..4435910 + 1107 WP_001299704.1 N-acetylneuraminate epimerase -
PL329_RS21660 (4435975) 4435975..4436955 + 981 WP_000991455.1 sialate O-acetylesterase -
PL329_RS21665 (4436963) 4436963..4437067 - 105 Protein_4228 HNH endonuclease -
PL329_RS21670 (4437167) 4437167..4437402 + 236 Protein_4229 HNH endonuclease -
PL329_RS21675 (4437670) 4437670..4438910 - 1241 Protein_4230 helicase YjhR -
PL329_RS21680 (4439026) 4439026..4439157 + 132 WP_001309182.1 hypothetical protein -
PL329_RS21685 (4439648) 4439648..4439905 + 258 WP_001054376.1 YjhX family toxin Toxin
PL329_RS21690 (4439917) 4439917..4440462 + 546 WP_001309181.1 N-acetyltransferase Antitoxin
PL329_RS21695 (4440518) 4440518..4441264 + 747 WP_000354252.1 class I SAM-dependent methyltransferase -
PL329_RS21700 (4441433) 4441433..4441651 + 219 Protein_4235 hypothetical protein -
PL329_RS21705 (4441689) 4441689..4441805 + 117 Protein_4236 VOC family protein -
PL329_RS21710 (4442050) 4442050..4443171 + 1122 WP_000010831.1 M42 family metallopeptidase -
PL329_RS21715 (4443168) 4443168..4443446 + 279 WP_000722973.1 PTS sugar transporter subunit IIB SgcB -
PL329_RS21720 (4443458) 4443458..4444771 + 1314 WP_000460843.1 PTS sugar transporter subunit IIC SgcC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimE / fimB 4430937..4448686 17749


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Putative toxin of bacterial toxin-antitoxin pair

(1-85)

Antitoxin

GNAT domain

(18-121)


Sequences

Toxin        


Download         Length: 86 a.a.        Molecular weight: 9734.29 Da        Isoelectric Point: 11.0090

>T268675 WP_001054376.1 NZ_CP116409:4439648-4439905 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR

Download         Length: 258 bp

Antitoxin


Download         Length: 182 a.a.        Molecular weight: 19956.90 Da        Isoelectric Point: 6.3277

>AT268675 WP_001309181.1 NZ_CP116409:4439917-4440462 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT

Download         Length: 546 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PA82

Antitoxin

Source ID Structure
AlphaFold DB U9Z4B8

References