Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3865130..3865748 Replicon chromosome
Accession NZ_CP116409
Organism Escherichia coli strain HH97

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag PL329_RS18980 Protein ID WP_001291435.1
Coordinates 3865530..3865748 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag PL329_RS18975 Protein ID WP_000344800.1
Coordinates 3865130..3865504 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL329_RS18965 (3860219) 3860219..3861412 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
PL329_RS18970 (3861435) 3861435..3864584 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
PL329_RS18975 (3865130) 3865130..3865504 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
PL329_RS18980 (3865530) 3865530..3865748 + 219 WP_001291435.1 HHA domain-containing protein Toxin
PL329_RS18985 (3865920) 3865920..3866471 + 552 WP_000102564.1 maltose O-acetyltransferase -
PL329_RS18990 (3866587) 3866587..3867057 + 471 WP_000136192.1 YlaC family protein -
PL329_RS18995 (3867221) 3867221..3868771 + 1551 WP_271710997.1 cyclic-guanylate-specific phosphodiesterase PdeB -
PL329_RS19000 (3868813) 3868813..3869166 - 354 WP_000878140.1 DUF1428 domain-containing protein -
PL329_RS19010 (3869545) 3869545..3869856 + 312 WP_000409911.1 MGMT family protein -
PL329_RS19015 (3869887) 3869887..3870459 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T268673 WP_001291435.1 NZ_CP116409:3865530-3865748 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT268673 WP_000344800.1 NZ_CP116409:3865130-3865504 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References