268672

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2747510..2749098 Replicon chromosome
Accession NZ_CP116409
Organism Escherichia coli strain HH97

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PL329_RS13395 Protein ID WP_271710912.1
Coordinates 2747776..2749098 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PL329_RS13390 Protein ID WP_001301023.1
Coordinates 2747510..2747776 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL329_RS13375 (2743868) 2743868..2745319 + 1452 WP_000854633.1 tagaturonate reductase -
PL329_RS13380 (2745526) 2745526..2746440 + 915 WP_001313828.1 bestrophin family protein -
PL329_RS13385 (2746444) 2746444..2747202 - 759 WP_001286597.1 trans-aconitate 2-methyltransferase -
PL329_RS13390 (2747510) 2747510..2747776 + 267 WP_001301023.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PL329_RS13395 (2747776) 2747776..2749098 + 1323 WP_271710912.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
PL329_RS13400 (2749440) 2749440..2749523 + 84 Protein_2612 hypothetical protein -
PL329_RS13405 (2749616) 2749616..2749776 + 161 Protein_2613 helix-turn-helix domain-containing protein -
PL329_RS13410 (2750210) 2750210..2750773 + 564 WP_000768280.1 type 1 fimbrial major subunit FimA -
PL329_RS13415 (2751135) 2751135..2751845 + 711 WP_001195181.1 fimbria/pilus periplasmic chaperone -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49328.86 Da        Isoelectric Point: 8.7817

>T268672 WP_271710912.1 NZ_CP116409:2747776-2749098 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTHPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWRIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLRFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVESNVLRLHGRLSREYGSK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10016.38 Da        Isoelectric Point: 6.2267

>AT268672 WP_001301023.1 NZ_CP116409:2747510-2747776 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSELAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDAKNASPES
TEQQNLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References