Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1190285..1190939 Replicon chromosome
Accession NZ_CP116409
Organism Escherichia coli strain HH97

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag PL329_RS05800 Protein ID WP_000244781.1
Coordinates 1190532..1190939 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag PL329_RS05795 Protein ID WP_000354046.1
Coordinates 1190285..1190551 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL329_RS05775 (1186254) 1186254..1187687 - 1434 WP_001338826.1 6-phospho-beta-glucosidase BglA -
PL329_RS05780 (1187732) 1187732..1188043 + 312 WP_001182954.1 N(4)-acetylcytidine aminohydrolase -
PL329_RS05785 (1188207) 1188207..1188866 + 660 WP_000250274.1 hemolysin III family protein -
PL329_RS05790 (1189062) 1189062..1190042 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
PL329_RS05795 (1190285) 1190285..1190551 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
PL329_RS05800 (1190532) 1190532..1190939 + 408 WP_000244781.1 protein YgfX Toxin
PL329_RS05805 (1190979) 1190979..1191500 - 522 WP_001055874.1 flavodoxin FldB -
PL329_RS05810 (1191612) 1191612..1192508 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
PL329_RS05815 (1192533) 1192533..1193243 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PL329_RS05820 (1193249) 1193249..1194982 + 1734 WP_271711177.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T268665 WP_000244781.1 NZ_CP116409:1190532-1190939 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT268665 WP_000354046.1 NZ_CP116409:1190285-1190551 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References