Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2918271..2918985 Replicon chromosome
Accession NC_017522
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name vapC Uniprot ID G0TQK0
Locus tag CCDC5180_RS13760 Protein ID WP_003413460.1
Coordinates 2918545..2918985 (+) Length 147 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P9WJ20
Locus tag CCDC5180_RS13755 Protein ID WP_003413456.1
Coordinates 2918271..2918558 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCDC5180_RS13720 2913692..2913937 + 246 WP_003413429.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
CCDC5180_RS13725 2913934..2914338 + 405 WP_003413432.1 type II toxin-antitoxin system VapC family toxin -
CCDC5180_RS13730 2914555..2915176 + 622 Protein_2675 DUF4178 domain-containing protein -
CCDC5180_RS13735 2915187..2915681 + 495 WP_003413444.1 DUF2617 family protein -
CCDC5180_RS13740 2915678..2916109 + 432 WP_003899390.1 DUF4247 domain-containing protein -
CCDC5180_RS13745 2916134..2916592 + 459 WP_003413451.1 DUF350 domain-containing protein -
CCDC5180_RS13750 2916589..2918160 + 1572 WP_003899392.1 polyamine aminopropyltransferase -
CCDC5180_RS13755 2918271..2918558 + 288 WP_003413456.1 antitoxin VapB41 Antitoxin
CCDC5180_RS13760 2918545..2918985 + 441 WP_003413460.1 type II toxin-antitoxin system VapC family toxin Toxin
CCDC5180_RS13765 2919006..2919761 - 756 WP_003413464.1 YebC/PmpR family DNA-binding transcriptional regulator -
CCDC5180_RS13770 2919894..2920490 - 597 WP_003413465.1 pyridoxal 5'-phosphate synthase glutaminase subunit PdxT -
CCDC5180_RS13775 2920498..2921343 - 846 WP_003413466.1 acyl-CoA thioesterase II -
CCDC5180_RS13780 2921372..2922271 - 900 WP_003413468.1 pyridoxal 5'-phosphate synthase lyase subunit PdxS -
CCDC5180_RS13785 2922399..2923073 + 675 WP_003413471.1 pyridoxamine 5'-phosphate oxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain toxin

(1-146)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 147 a.a.        Molecular weight: 16026.38 Da        Isoelectric Point: 6.8599

>T26866 WP_003413460.1 NC_017522:2918545-2918985 [Mycobacterium tuberculosis CCDC5180]
MLLCDTNIWLALALSGHVHHRASRAWLDTINAPGVIHFCRATQQSLLRLLTNRTVLGAYGSPPLTNREAWAAYAAFLDDD
RIVLAGAEPDGLEAQWRAFAVRQSPAPKVWMDAYLAAFALTGGFELVTTDTAFTQYGGIELRLLAK

Download         Length: 441 bp

>T26866 NC_017522:2918545-2918985 [Mycobacterium tuberculosis CCDC5180]
ATGCTGCTCTGTGACACCAACATCTGGCTGGCGTTGGCGCTTTCCGGACACGTGCACCACAGGGCCTCGCGCGCATGGCT
AGACACCATCAACGCGCCCGGAGTCATCCACTTTTGCCGCGCAACCCAACAGTCGCTCCTTCGGCTGTTGACGAATCGGA
CGGTGCTGGGCGCGTATGGCAGCCCACCACTGACCAACCGCGAAGCGTGGGCGGCCTATGCCGCGTTCCTGGATGACGAC
CGCATCGTGCTGGCCGGCGCCGAACCTGATGGTTTGGAGGCCCAGTGGAGAGCCTTCGCCGTTCGCCAGTCGCCGGCGCC
CAAGGTTTGGATGGATGCCTACCTAGCTGCTTTCGCACTTACCGGTGGATTCGAGTTGGTGACGACTGACACCGCCTTCA
CCCAGTACGGCGGAATCGAGCTGCGGCTCCTGGCCAAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10453.98 Da        Isoelectric Point: 7.2797

>AT26866 WP_003413456.1 NC_017522:2918271-2918558 [Mycobacterium tuberculosis CCDC5180]
MKTTLDLPDELMRAIKVRAAQQGRKMKDVVTELLRSGLSQTHSGAPIPTPRRVQLPLVHCGGAATREQEMTPERVAAALL
DQEAQWWSGHDDAAL

Download         Length: 288 bp

>AT26866 NC_017522:2918271-2918558 [Mycobacterium tuberculosis CCDC5180]
ATGAAGACCACGCTCGACCTGCCTGATGAACTGATGCGCGCTATCAAGGTCCGCGCGGCGCAGCAGGGCCGCAAGATGAA
AGATGTCGTGACCGAACTGCTCAGATCCGGTCTGTCCCAGACGCACAGCGGGGCTCCAATCCCAACGCCGCGGCGCGTGC
AGCTTCCCCTGGTGCATTGCGGTGGCGCGGCTACCCGCGAACAAGAAATGACGCCGGAGCGTGTTGCCGCGGCCTTGCTC
GACCAGGAGGCCCAGTGGTGGTCCGGACACGACGATGCTGCTCTGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQK0

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4BWB8

References