Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4081737..4082313 Replicon chromosome
Accession NZ_CP116405
Organism Escherichia coli strain HH107

Toxin (Protein)


Gene name shpA Uniprot ID D3GXZ2
Locus tag PL328_RS19965 Protein ID WP_001297643.1
Coordinates 4082026..4082313 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A829G8Z0
Locus tag PL328_RS19960 Protein ID WP_000063156.1
Coordinates 4081737..4082039 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL328_RS19945 (4078333) 4078333..4080483 + 2151 WP_001295524.1 pyruvate/proton symporter BtsT -
PL328_RS19950 (4080533) 4080533..4080736 + 204 WP_000467859.1 YbdD/YjiX family protein -
PL328_RS19955 (4080747) 4080747..4081703 + 957 WP_001297640.1 GTPase -
PL328_RS19960 (4081737) 4081737..4082039 - 303 WP_000063156.1 BrnA antitoxin family protein Antitoxin
PL328_RS19965 (4082026) 4082026..4082313 - 288 WP_001297643.1 BrnT family toxin Toxin
PL328_RS19970 (4082512) 4082512..4083209 - 698 Protein_3908 IS1 family transposase -
PL328_RS19975 (4083266) 4083266..4083361 + 96 Protein_3909 dienelactone hydrolase family protein -
PL328_RS19980 (4083507) 4083507..4084739 + 1233 WP_001339512.1 multidrug efflux MFS transporter MdtM -
PL328_RS19985 (4084780) 4084780..4086060 + 1281 WP_001037380.1 DUF445 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11295.77 Da        Isoelectric Point: 6.8821

>T268658 WP_001297643.1 NZ_CP116405:c4082313-4082026 [Escherichia coli]
MPMEFEWDENKAKSNRVKHGIRFEDAVLLFDDPQHLSQQERIENGEYRWQTIGLVYGIVVILVAHTIRFESGNEIIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11521.99 Da        Isoelectric Point: 9.4646

>AT268658 WP_000063156.1 NZ_CP116405:c4082039-4081737 [Escherichia coli]
MSMVKHKRGTSSTLDVQHEAELKALANKSDEDIDYSDIPPSSDEQWSNAERGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GEV9

Antitoxin

Source ID Structure
AlphaFold DB A0A829G8Z0

References