268654

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2455921..2456559 Replicon chromosome
Accession NZ_CP116405
Organism Escherichia coli strain HH107

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag PL328_RS11865 Protein ID WP_000813794.1
Coordinates 2456383..2456559 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag PL328_RS11860 Protein ID WP_001270286.1
Coordinates 2455921..2456337 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL328_RS11840 (2451073) 2451073..2452014 - 942 WP_001251304.1 ABC transporter permease -
PL328_RS11845 (2452015) 2452015..2453028 - 1014 WP_000220396.1 ABC transporter ATP-binding protein -
PL328_RS11850 (2453046) 2453046..2454191 - 1146 WP_000047424.1 ABC transporter substrate-binding protein -
PL328_RS11855 (2454436) 2454436..2455842 - 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
PL328_RS11860 (2455921) 2455921..2456337 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
PL328_RS11865 (2456383) 2456383..2456559 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
PL328_RS11870 (2456781) 2456781..2457011 + 231 WP_000494244.1 YncJ family protein -
PL328_RS11875 (2457103) 2457103..2459064 - 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
PL328_RS11880 (2459137) 2459137..2459673 - 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
PL328_RS11885 (2459765) 2459765..2460940 + 1176 WP_001236265.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T268654 WP_000813794.1 NZ_CP116405:c2456559-2456383 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT268654 WP_001270286.1 NZ_CP116405:c2456337-2455921 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References