Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/HTH_IclR(antitoxin)
Location 2783882..2785638 Replicon chromosome
Accession NZ_CP116404
Organism Burkholderia pseudomallei strain MSHR5087

Toxin (Protein)


Gene name doc Uniprot ID C4APV8
Locus tag PL318_RS29010 Protein ID WP_004195452.1
Coordinates 2784733..2785638 (-) Length 302 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID Q63LW2
Locus tag PL318_RS29005 Protein ID WP_004195450.1
Coordinates 2783882..2784736 (-) Length 285 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL318_RS28985 (PL318_28985) 2779098..2780588 - 1491 WP_004524006.1 aldehyde dehydrogenase -
PL318_RS28990 (PL318_28990) 2780614..2781429 - 816 WP_004195445.1 aspartate dehydrogenase -
PL318_RS28995 (PL318_28995) 2781422..2783095 - 1674 WP_004524004.1 thiamine pyrophosphate-binding protein -
PL318_RS29000 (PL318_29000) 2783088..2783885 - 798 WP_004540865.1 SDR family oxidoreductase -
PL318_RS29005 (PL318_29005) 2783882..2784736 - 855 WP_004195450.1 IclR family transcriptional regulator Antitoxin
PL318_RS29010 (PL318_29010) 2784733..2785638 - 906 WP_004195452.1 alpha/beta fold hydrolase Toxin
PL318_RS29015 (PL318_29015) 2785655..2786182 - 528 WP_004524001.1 cupin domain-containing protein -
PL318_RS29020 (PL318_29020) 2786221..2786991 - 771 WP_004524000.1 SDR family oxidoreductase -
PL318_RS29025 (PL318_29025) 2786988..2788055 - 1068 WP_004195457.1 aromatic ring-hydroxylating dioxygenase subunit alpha -
PL318_RS29030 (PL318_29030) 2788090..2788401 - 312 WP_038735665.1 hypothetical protein -
PL318_RS29035 (PL318_29035) 2788403..2788720 - 318 WP_004184916.1 non-heme iron oxygenase ferredoxin subunit -
PL318_RS29040 (PL318_29040) 2789155..2790243 + 1089 WP_004184835.1 porin -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Alpha/beta hydrolase fold-1

(54-284)

Antitoxin

Transcription regulator IclR, C-terminal

(143-265)


Sequences

Toxin        


Download         Length: 302 a.a.        Molecular weight: 30555.70 Da        Isoelectric Point: 8.7357

>T268643 WP_004195452.1 NZ_CP116404:c2785638-2784733 [Burkholderia pseudomallei]
MSTISTTTTEAGAAPFAALLARFPERRAAVGGAGVIGYREAGEAHARRAGCEPVVLLHGIGSGAASWVRQLDALGATRRA
LAWDAPGYGASSRVAADSPVAADYAASLAAWLDALRIQRCVLVGHSLGAIMAGAFARIAGERLAGLLLISPAGGYGSAPA
DVRAGRRDSRLALLASLGPQGLAAERSANMLSAQASGAAREWVRWNMARIAPAGYAQATHLLANADLASDLAHCRGRIAV
AVGGDDAITPPAACERIARAAGVGLQVIARAGHAGYVEAPDAYSALIDAFCRQCDGSRGTP

Download         Length: 906 bp

Antitoxin


Download         Length: 285 a.a.        Molecular weight: 31152.56 Da        Isoelectric Point: 6.8932

>AT268643 WP_004195450.1 NZ_CP116404:c2784736-2783882 [Burkholderia pseudomallei]
MSEPLLKDADDARNDSNYVVPGLERGLRILAEFSPREPVLGAPELSKRLGIPRTTVFRLLQTLESLGFLERADKDRNYRL
GVAVLRLGFEYLSSLELTDLGLPVIESLRDATGFTAHIVIRDGRDVVFVAKAQNAGNAFGSVRVNVGTRLPAHATTHGHV
LMGDLSLAQLRALYPERALERVTKATPETVDALFDVIRDDARRGYGIGNSAFERDISVVTAPVRNEASRIVAVVTVTVPR
PEIDAALVAEGLVEKVVRAAAELSRRLNYRSDDENTYLKALGLR

Download         Length: 855 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N4FRK3

Antitoxin

Source ID Structure
AlphaFold DB A0A3N4FRW8

References