268642

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT_toxin-BrnA
Location 1580910..1581447 Replicon chromosome
Accession NZ_CP116404
Organism Burkholderia pseudomallei strain MSHR5087

Toxin (Protein)


Gene name brnT Uniprot ID -
Locus tag PL318_RS24285 Protein ID WP_009923450.1
Coordinates 1580910..1581179 (+) Length 90 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID Q63NA3
Locus tag PL318_RS24290 Protein ID WP_004525420.1
Coordinates 1581163..1581447 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL318_RS24240 (PL318_24240) 1576689..1577117 - 429 Protein_1347 integrase core domain-containing protein -
PL318_RS24245 (PL318_24245) 1577316..1577849 - 534 Protein_1348 SPFH domain-containing protein -
PL318_RS24250 (PL318_24250) 1577885..1578034 - 150 WP_004537646.1 bacteriophage protein Gp44 -
PL318_RS24255 (PL318_24255) 1578283..1578936 + 654 WP_004545536.1 hypothetical protein -
PL318_RS24260 (PL318_24260) 1579122..1579340 - 219 WP_004552392.1 hypothetical protein -
PL318_RS24265 (PL318_24265) 1579388..1579546 - 159 WP_004549802.1 hypothetical protein -
PL318_RS24270 (PL318_24270) 1579543..1579785 - 243 WP_004545584.1 hypothetical protein -
PL318_RS24275 (PL318_24275) 1579923..1580054 - 132 WP_009923452.1 bacteriophage protein Gp48 -
PL318_RS24280 (PL318_24280) 1580064..1580339 - 276 WP_004552388.1 bacteriophage protein Gp49 -
PL318_RS24285 (PL318_24285) 1580910..1581179 + 270 WP_009923450.1 BrnT family toxin Toxin
PL318_RS24290 (PL318_24290) 1581163..1581447 + 285 WP_004525420.1 BrnA antitoxin family protein Antitoxin
PL318_RS24300 (PL318_24300) 1582094..1582477 + 384 Protein_1358 integrase core domain-containing protein -
PL318_RS24305 (PL318_24305) 1582476..1582868 + 393 Protein_1359 IS110 family transposase -
PL318_RS24310 (PL318_24310) 1583095..1583211 - 117 Protein_1360 transposase -
PL318_RS24315 (PL318_24315) 1583458..1584918 + 1461 WP_038737257.1 metallophosphoesterase -
PL318_RS24320 (PL318_24320) 1585077..1586339 + 1263 WP_009975402.1 cytochrome c peroxidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1560792..1584918 24126


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(5-81)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(27-88)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10156.52 Da        Isoelectric Point: 7.1633

>T268642 WP_009923450.1 NZ_CP116404:1580910-1581179 [Burkholderia pseudomallei]
MDITFDPTKNKTNIAKHGVSLALAAQLDWSDVLSYVDDRRDYSEVREVGFGVIGDRLYCVVFTQRGDSMHIISMRKANKR
EVKSYVEQA

Download         Length: 270 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10697.10 Da        Isoelectric Point: 5.8930

>AT268642 WP_004525420.1 NZ_CP116404:1581163-1581447 [Burkholderia pseudomallei]
MSSKRKIVMPTDEEDAAINRGIAADPDTFEVPAEDFAKMTRRGKRGRPPLEAPKVQLTVRYDVDIVDAFKATGEGWQTRM
NDALREWLREHQPA

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A0F6L9S8

References