Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 34841..36600 Replicon chromosome
Accession NZ_CP116404
Organism Burkholderia pseudomallei strain MSHR5087

Toxin (Protein)


Gene name hipA Uniprot ID Q63JY0
Locus tag PL318_RS17600 Protein ID WP_004188815.1
Coordinates 35248..36600 (+) Length 451 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID C4I768
Locus tag PL318_RS17595 Protein ID WP_004536731.1
Coordinates 34841..35251 (+) Length 137 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL318_RS17580 (PL318_17580) 29856..31373 - 1518 WP_045720440.1 cellulose synthase complex periplasmic endoglucanase BcsZ -
PL318_RS17585 (PL318_17585) 31378..33774 - 2397 WP_076842108.1 cellulose biosynthesis cyclic di-GMP-binding regulatory protein BcsB -
PL318_RS17590 (PL318_17590) 34240..34503 + 264 WP_004199789.1 hypothetical protein -
PL318_RS17595 (PL318_17595) 34841..35251 + 411 WP_004536731.1 helix-turn-helix domain-containing protein Antitoxin
PL318_RS17600 (PL318_17600) 35248..36600 + 1353 WP_004188815.1 type II toxin-antitoxin system HipA family toxin Toxin
PL318_RS17605 (PL318_17605) 36757..37164 - 408 WP_045720444.1 hypothetical protein -
PL318_RS17610 (PL318_17610) 37265..37411 - 147 WP_004199790.1 hypothetical protein -
PL318_RS17615 (PL318_17615) 37602..38516 - 915 WP_045720445.1 LysR family transcriptional regulator -
PL318_RS17620 (PL318_17620) 38683..39636 + 954 WP_004187785.1 agmatinase -
PL318_RS17625 (PL318_17625) 39907..40248 + 342 WP_004525272.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(158-408)

Antitoxin

Cro/C1-type helix-turn-helix domain

(22-71)


Sequences

Toxin        


Download         Length: 451 a.a.        Molecular weight: 49848.83 Da        Isoelectric Point: 9.6807

>T268641 WP_004188815.1 NZ_CP116404:35248-36600 [Burkholderia pseudomallei]
VSARRARATRLHLWMNGLPVGYWEHARDGERLVYFDEWIGDPQGRPLSLSLPFTPGNQPYRGRLVSDYFDNLLPDSEPIR
RRIAMRYRTGGTSAFALLATLGRDCVGALQMLPPDEAPDDIERIRGHALADADIARLLREVTSAPQAGRHAPLDDLRLSI
AGAQEKTALLRHRGRWLLPEGSTPTTHILKLPLGLVGNRRADMRTSVENEWLCARIVAAYGLPVARCDIAQFDDQKALVV
ERFDRRPSRDARWLLRLPQEDMCQATGTSALDKYQADGGPGIETIMEVLAGSEHARDDRRAFFAAQIVFWLLAATDGHAK
NFSIAHLPGNRYRSTPLYDVLSAHPVIGRGANQLPAQRARLAMGVRGKHIHYPLHQIRRRHWIAQGQRVGFAPADVDALI
DTLTARTADVVDAVSARLPRDFPRDVADAIFSGMLGLSARLAGDAAARAP

Download         Length: 1353 bp

Antitoxin


Download         Length: 137 a.a.        Molecular weight: 14508.87 Da        Isoelectric Point: 11.8540

>AT268641 WP_004536731.1 NZ_CP116404:34841-35251 [Burkholderia pseudomallei]
MAILIEHEIKTLGQLRPILRGFRKSAGLTQAMLASRLGVTQQTYAQFEANPASASVERLFKVLRALDIELTLTLTQVYAA
PAGKDKGEVAKTAAGARARAGARRAVPPASAPAPSAAGRAPRPARKRAAPKKREDW

Download         Length: 411 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3N4FSX2

Antitoxin

Source ID Structure
AlphaFold DB A0A7V8KZI9

References