Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 3434444..3435049 Replicon chromosome
Accession NZ_CP116398
Organism Methylomonas sp. EFPC3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PL263_RS15375 Protein ID WP_256608988.1
Coordinates 3434753..3435049 (-) Length 99 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag PL263_RS15370 Protein ID WP_256608987.1
Coordinates 3434444..3434749 (-) Length 102 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL263_RS15350 (PL263_15345) 3430391..3431359 - 969 WP_278210150.1 DUF882 domain-containing protein -
PL263_RS15355 (PL263_15350) 3431553..3432440 - 888 WP_278210151.1 inositol monophosphatase family protein -
PL263_RS15360 (PL263_15355) 3432443..3433417 - 975 WP_278210152.1 phosphotransferase -
PL263_RS15365 (PL263_15360) 3433465..3434265 - 801 WP_278210153.1 indole-3-glycerol phosphate synthase TrpC -
PL263_RS15370 (PL263_15365) 3434444..3434749 - 306 WP_256608987.1 putative addiction module antidote protein Antitoxin
PL263_RS15375 (PL263_15370) 3434753..3435049 - 297 WP_256608988.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PL263_RS15380 (PL263_15375) 3435089..3436105 - 1017 WP_278210154.1 anthranilate phosphoribosyltransferase -
PL263_RS15385 (PL263_15380) 3436235..3437425 - 1191 WP_278210155.1 trans-2-enoyl-CoA reductase family protein -
PL263_RS15390 (PL263_15385) 3437734..3438342 + 609 WP_278210156.1 discoidin domain-containing protein -
PL263_RS15395 (PL263_15390) 3438631..3439026 - 396 WP_278210157.1 hypothetical protein -
PL263_RS15400 (PL263_15395) 3439112..3439780 - 669 WP_278210158.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-93)

Antitoxin

Uncharacterized protein HI1420

(13-100)


Sequences

Toxin        


Download         Length: 99 a.a.        Molecular weight: 10940.64 Da        Isoelectric Point: 8.0276

>T268640 WP_256608988.1 NZ_CP116398:c3435049-3434753 [Methylomonas sp. EFPC3]
MYTIKQLPAFSEWLFGLKDGLTHRRLARRLEKAQQGNLGDVKAVGEGVFEMREHFGPGWRMYYVQRGEVLIVMLGGGDKS
SQAADIAKAQCLAALLED

Download         Length: 297 bp

Antitoxin


Download         Length: 102 a.a.        Molecular weight: 10876.50 Da        Isoelectric Point: 5.1356

>AT268640 WP_256608987.1 NZ_CP116398:c3434749-3434444 [Methylomonas sp. EFPC3]
MNEKIKIADLPVFDITEHLDSDQAIAEYLTVVLEEDDPAALAHALGSIARARGMTEIANAAGISREALYKALRADAQPRF
ETIAKVCKALGVKLTVQTRAA

Download         Length: 306 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References