Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/LOTUS_5_Limkain_b1(toxin)
Location 2856806..2857437 Replicon chromosome
Accession NC_017522
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name vapC Uniprot ID G0TQ28
Locus tag CCDC5180_RS13485 Protein ID WP_003413174.1
Coordinates 2857060..2857437 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID P95006
Locus tag CCDC5180_RS13480 Protein ID WP_003413167.1
Coordinates 2856806..2857063 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCDC5180_RS13455 2852751..2853035 + 285 WP_042509291.1 hypothetical protein -
CCDC5180_RS13460 2853331..2854542 + 1212 WP_003900845.1 alpha/beta hydrolase family protein -
CCDC5180_RS13465 2854669..2855328 + 660 WP_003902296.1 hypothetical protein -
CCDC5180_RS13470 2855325..2855987 + 663 WP_003905878.1 hypothetical protein -
CCDC5180_RS22355 2855984..2856261 + 278 Protein_2623 type II toxin-antitoxin system VapB family antitoxin -
CCDC5180_RS13475 2856354..2856767 + 414 WP_003413164.1 PIN domain nuclease -
CCDC5180_RS13480 2856806..2857063 + 258 WP_003413167.1 ribbon-helix-helix domain-containing protein Antitoxin
CCDC5180_RS13485 2857060..2857437 + 378 WP_003413174.1 type II toxin-antitoxin system VapC family toxin Toxin
CCDC5180_RS13490 2857453..2857827 - 375 WP_003413177.1 hypothetical protein -
CCDC5180_RS13495 2857927..2858322 - 396 WP_003413180.1 type II toxin-antitoxin system toxin 23S rRNA-specific endonuclease VapC20 -
CCDC5180_RS13500 2858319..2858564 - 246 WP_003413183.1 type II toxin-antitoxin system antitoxin VapB20 -
CCDC5180_RS13505 2858975..2859394 - 420 WP_003413190.1 A24 family peptidase -
CCDC5180_RS13510 2859406..2860215 - 810 WP_003413193.1 shikimate dehydrogenase -
CCDC5180_RS13515 2860212..2861465 - 1254 WP_003413196.1 endolytic transglycosylase MltG -
CCDC5180_RS13520 2861458..2861970 - 513 WP_003413197.1 Holliday junction resolvase RuvX -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-111)

Antitoxin

Ribbon-helix-helix protein, CopG

(2-38)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13728.72 Da        Isoelectric Point: 4.4687

>T26864 WP_003413174.1 NC_017522:2857060-2857437 [Mycobacterium tuberculosis CCDC5180]
VKLIDTTIAVDHLRGEPAAAVLLAELINNGEEIAASELVRFELLAGVRESELAALEAFFSAVVWTLVTEDIARIGGRLAR
RYRSSHRGIDDVDYLIAATAIVVDADLLTTNVRHFPMFPDLQPPY

Download         Length: 378 bp

>T26864 NC_017522:2857060-2857437 [Mycobacterium tuberculosis CCDC5180]
GTGAAGCTGATCGACACCACCATCGCGGTCGACCACCTTCGCGGCGAACCCGCGGCAGCCGTGCTGCTCGCCGAACTGAT
AAACAACGGTGAGGAGATCGCGGCCAGCGAGCTGGTCCGATTCGAACTCCTCGCCGGTGTGCGGGAAAGCGAACTCGCGG
CGCTCGAGGCCTTCTTCTCGGCAGTGGTGTGGACCCTGGTGACCGAGGACATTGCCCGGATCGGCGGACGACTCGCCCGT
CGATACCGGTCCAGCCACCGCGGTATCGACGACGTGGACTACCTGATCGCTGCGACCGCCATTGTGGTCGACGCCGACCT
GCTCACCACCAATGTGCGCCACTTCCCGATGTTCCCGGATCTGCAGCCGCCGTACTGA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9453.63 Da        Isoelectric Point: 10.6555

>AT26864 WP_003413167.1 NC_017522:2856806-2857063 [Mycobacterium tuberculosis CCDC5180]
MRTQVTLGKEELELLDRAAKASGASRSELIRRAIHRAYGTGSKQERLAALDHSRGSWRGRDFTGTEYVDAIRGDLNERLA
RLGLA

Download         Length: 258 bp

>AT26864 NC_017522:2856806-2857063 [Mycobacterium tuberculosis CCDC5180]
ATGCGGACTCAGGTGACCCTGGGCAAAGAGGAGCTTGAGCTGCTCGATCGTGCCGCCAAGGCGAGTGGCGCATCGCGGTC
CGAACTCATCCGACGCGCAATTCACCGTGCCTACGGGACTGGATCCAAGCAGGAACGGCTCGCCGCGCTCGACCACAGCC
GTGGCTCGTGGCGAGGACGGGACTTCACCGGCACCGAGTATGTCGACGCCATTCGGGGCGACCTCAACGAACGACTTGCT
CGGCTCGGTCTGGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TQ28

Antitoxin

Source ID Structure
AlphaFold DB A0A829C9W5

References