Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/YoeB-YefM
Location 1952590..1953098 Replicon chromosome
Accession NZ_CP116398
Organism Methylomonas sp. EFPC3

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PL263_RS08735 Protein ID WP_278212651.1
Coordinates 1952590..1952850 (-) Length 87 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID A0A1S1Y940
Locus tag PL263_RS08740 Protein ID WP_071155240.1
Coordinates 1952847..1953098 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL263_RS08705 (PL263_08700) 1947793..1948566 + 774 WP_278212864.1 ABC transporter ATP-binding protein -
PL263_RS08710 (PL263_08705) 1948658..1948960 + 303 WP_278212646.1 hypothetical protein -
PL263_RS08715 (PL263_08710) 1948979..1949830 + 852 WP_278212647.1 urease accessory protein UreD -
PL263_RS08720 (PL263_08715) 1950250..1951554 + 1305 WP_278212648.1 P-loop NTPase fold protein -
PL263_RS08725 (PL263_08720) 1951655..1952185 + 531 WP_278212649.1 transposase -
PL263_RS08730 (PL263_08725) 1952217..1952600 - 384 WP_278212650.1 hypothetical protein -
PL263_RS08735 (PL263_08730) 1952590..1952850 - 261 WP_278212651.1 Txe/YoeB family addiction module toxin Toxin
PL263_RS08740 (PL263_08735) 1952847..1953098 - 252 WP_071155240.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
PL263_RS08745 (PL263_08740) 1953228..1953530 + 303 WP_278212652.1 urease subunit gamma -
PL263_RS08750 (PL263_08745) 1953660..1953977 + 318 WP_140914403.1 urease subunit beta -
PL263_RS08755 (PL263_08750) 1953974..1955677 + 1704 WP_278212653.1 urease subunit alpha -
PL263_RS08760 (PL263_08755) 1955867..1956298 + 432 WP_278212654.1 urease accessory protein UreE -
PL263_RS08765 (PL263_08760) 1956288..1956962 + 675 WP_278212655.1 urease accessory protein UreF -
PL263_RS08770 (PL263_08765) 1957051..1957668 + 618 WP_140914399.1 urease accessory protein UreG -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(5-84)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-74)


Sequences

Toxin        


Download         Length: 87 a.a.        Molecular weight: 10224.66 Da        Isoelectric Point: 9.3056

>T268639 WP_278212651.1 NZ_CP116398:c1952850-1952590 [Methylomonas sp. EFPC3]
VKITFSSDAWDSYLYWQATDKAILKRINQLIKEIQRQPFEGIGKPEPLQHGLSGYWSRRINDEHRIVYKVAGDTLLIAQL
RFHYEY

Download         Length: 261 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9184.45 Da        Isoelectric Point: 4.4621

>AT268639 WP_071155240.1 NZ_CP116398:c1953098-1952847 [Methylomonas sp. EFPC3]
MDAISYSAARANLAKTMDKVCADHAPIIITRKSESPVVMLSLEDYQAMEETAYLLRSPANARRLLESIAELESGQGTERE
LIE

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1S1Y940

References