Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 12252..12891 Replicon chromosome
Accession NZ_CP116398
Organism Methylomonas sp. EFPC3

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag PL263_RS00060 Protein ID WP_278211098.1
Coordinates 12252..12653 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A291IN90
Locus tag PL263_RS00065 Protein ID WP_054761998.1
Coordinates 12658..12891 (-) Length 78 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PL263_RS00045 (PL263_00045) 9585..10469 + 885 WP_278211095.1 LysR family transcriptional regulator -
PL263_RS00050 (PL263_00050) 10766..11011 + 246 WP_278211096.1 type II toxin-antitoxin system CcdA family antitoxin -
PL263_RS00055 (PL263_00055) 11011..11322 + 312 WP_278211097.1 CcdB family protein -
PL263_RS00060 (PL263_00060) 12252..12653 - 402 WP_278211098.1 type II toxin-antitoxin system VapC family toxin Toxin
PL263_RS00065 (PL263_00065) 12658..12891 - 234 WP_054761998.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
PL263_RS00070 (PL263_00070) 13053..13466 - 414 WP_278211100.1 type II toxin-antitoxin system VapC family toxin -
PL263_RS00075 (PL263_00075) 13463..13717 - 255 WP_278211102.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein -
PL263_RS00080 (PL263_00080) 14255..17149 + 2895 WP_278211103.1 ribonucleoside-diphosphate reductase subunit alpha -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-56)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14844.24 Da        Isoelectric Point: 8.9485

>T268635 WP_278211098.1 NZ_CP116398:c12653-12252 [Methylomonas sp. EFPC3]
VLKYLLDTNIVIYVIKRRPIEVLATFNRHHGRMAISAVTLAELIHGAEKSQFPARNLATVEDFCSRLQVLPYNDSAALHY
GGIRAALEKIGQPIGVNDLHIAAHARSHGLILVSNNLREFARVPGLLMENWLE

Download         Length: 402 bp

Antitoxin


Download         Length: 78 a.a.        Molecular weight: 8618.53 Da        Isoelectric Point: 4.4883

>AT268635 WP_054761998.1 NZ_CP116398:c12891-12658 [Methylomonas sp. EFPC3]
MATSTVFTNNRSQAVRLPADMRFPDSVKKVEVRAVGQERIIAPADAAWDSFFLDGPSVSDDFLNERPSQQQGERESF

Download         Length: 234 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A291IN90

References