Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 2258895..2259381 Replicon chromosome
Accession NZ_CP116393
Organism Streptococcus suis strain SS/UPM/MY/F001

Toxin (Protein)


Gene name relE Uniprot ID D5AGV2
Locus tag PFZ59_RS11485 Protein ID WP_011922754.1
Coordinates 2258895..2259164 (-) Length 90 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D5AGV1
Locus tag PFZ59_RS11490 Protein ID WP_002938604.1
Coordinates 2259154..2259381 (-) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFZ59_RS11465 (PFZ59_11465) 2254728..2255702 - 975 WP_024400159.1 YvcK family protein -
PFZ59_RS11470 (PFZ59_11470) 2255699..2256586 - 888 WP_024412169.1 RNase adapter RapZ -
PFZ59_RS11475 (PFZ59_11475) 2256608..2256985 - 378 WP_029171852.1 RidA family protein -
PFZ59_RS11480 (PFZ59_11480) 2257169..2258488 - 1320 WP_277697127.1 MATE family efflux transporter -
PFZ59_RS11485 (PFZ59_11485) 2258895..2259164 - 270 WP_011922754.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PFZ59_RS11490 (PFZ59_11490) 2259154..2259381 - 228 WP_002938604.1 DUF6290 family protein Antitoxin
PFZ59_RS11495 (PFZ59_11495) 2259608..2260864 + 1257 WP_277697779.1 ISL3 family transposase -
PFZ59_RS11500 (PFZ59_11500) 2260916..2262262 - 1347 WP_024377171.1 asparagine--tRNA ligase -
PFZ59_RS11505 (PFZ59_11505) 2262277..2263458 - 1182 WP_208582189.1 pyridoxal phosphate-dependent aminotransferase -
PFZ59_RS11510 (PFZ59_11510) 2263455..2263952 - 498 WP_208582187.1 DUF5590 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 2259572..2260864 1292


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-87)

Antitoxin

Protein of unknown function DUF6290

(1-71)


Sequences

Toxin        


Download         Length: 90 a.a.        Molecular weight: 10437.49 Da        Isoelectric Point: 10.3916

>T268634 WP_011922754.1 NZ_CP116393:c2259164-2258895 [Streptococcus suis]
MAYKLVLSDDALKQLKKMDRHVGMMLAKDLKKRLDGLENPRQFGKALVGDYKGLWRYRVGNYRVICDIIDNKMVILALEI
GHRKEIYKK

Download         Length: 270 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8450.51 Da        Isoelectric Point: 4.1589

>AT268634 WP_002938604.1 NZ_CP116393:c2259381-2259154 [Streptococcus suis]
MGIVSLRLNDAEEEIFRSYAIHTGKSLSELFKTALAEQIEDQLDYEIGIKALKKFQENPVTHSIDDVLAELEDGL

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A126UKS2

Antitoxin

Source ID Structure
AlphaFold DB A0A140EXF0

References