Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sezT-pezT/zeta-couple_hipB
Location 243095..244347 Replicon chromosome
Accession NZ_CP116393
Organism Streptococcus suis strain SS/UPM/MY/F001

Toxin (Protein)


Gene name sezT Uniprot ID -
Locus tag PFZ59_RS01255 Protein ID WP_063077076.1
Coordinates 243095..243871 (-) Length 259 a.a.

Antitoxin (Protein)


Gene name pezT Uniprot ID -
Locus tag PFZ59_RS01260 Protein ID WP_063077077.1
Coordinates 243871..244347 (-) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PFZ59_RS01240 (PFZ59_01240) 238316..239209 - 894 WP_063077082.1 restriction endonuclease -
PFZ59_RS01245 (PFZ59_01245) 239234..242317 - 3084 WP_202846937.1 DEAD/DEAH box helicase -
PFZ59_RS01250 (PFZ59_01250) 242314..243111 - 798 WP_202846938.1 SAVED domain-containing protein -
PFZ59_RS01255 (PFZ59_01255) 243095..243871 - 777 WP_063077076.1 type II toxin-antitoxin system toxin PezT Toxin
PFZ59_RS01260 (PFZ59_01260) 243871..244347 - 477 WP_063077077.1 type II toxin-antitoxin system antitoxin PezA Antitoxin
PFZ59_RS01265 (PFZ59_01265) 244661..245329 + 669 WP_208581057.1 aquaporin -
PFZ59_RS01270 (PFZ59_01270) 245373..245987 - 615 WP_044751282.1 CoA pyrophosphatase -
PFZ59_RS01275 (PFZ59_01275) 246100..247632 - 1533 WP_208581054.1 DUF853 family protein -
PFZ59_RS01280 (PFZ59_01280) 247902..248702 + 801 WP_044753092.1 formate/nitrite transporter family protein -
PFZ59_RS01285 (PFZ59_01285) 248877..249203 + 327 WP_002937550.1 PadR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(29-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 259 a.a.        Molecular weight: 29382.29 Da        Isoelectric Point: 6.1674

>T268630 WP_063077076.1 NZ_CP116393:c243871-243095 [Streptococcus suis]
MRLEEFSEADFQKALQRTIRVLTRGKTIPGQPKAILLGGQSGAGKTTVHRIKQKEFQGNIIIIDGDSYRSQHPNYLALQE
KYGKDSVDHTKGFAGKMVEHLVDELSMQGYHLLIEGTLRTTQVPRQTAQLLASKGYQVSLAVIGTKPELSYLSTLIRYEE
LYAIDPNQARATPKEHHDGIVENLVDNLRELEREQLFDCIQIYQRDRTCIYDSKTDEGSAAEVLQECLFGKWSKVEEEMM
KFGQERLWEMSKSNGNDV

Download         Length: 777 bp

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18259.60 Da        Isoelectric Point: 4.2553

>AT268630 WP_063077077.1 NZ_CP116393:c244347-243871 [Streptococcus suis]
MIGDNIKSLRQTHDLTQPEFAKMVGISRNSLSRYENGTSTVSTELIDRICQKFNVSYVDIVGEDKMLTPVEDYQLTLKVE
VIKERGAAILSQLYRYQDSQDIAFDDETNPWILMSDDLAELINTQIYLVDTFDEIERYNGYLDGIERMLDMVHHRVVA

Download         Length: 477 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References