Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/PIN-RelB
Location 2130032..2130912 Replicon chromosome
Accession NZ_CP116390
Organism Bifidobacterium longum strain LBUX23

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag PIB40_RS08970 Protein ID WP_271710385.1
Coordinates 2130421..2130912 (+) Length 164 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID F8APN1
Locus tag PIB40_RS08965 Protein ID WP_007057212.1
Coordinates 2130032..2130424 (+) Length 131 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PIB40_RS08960 (PIB40_08960) 2127188..2129887 + 2700 WP_013582802.1 aconitate hydratase AcnA -
PIB40_RS08965 (PIB40_08965) 2130032..2130424 + 393 WP_007057212.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PIB40_RS08970 (PIB40_08970) 2130421..2130912 + 492 WP_271710385.1 type II toxin-antitoxin system VapC family toxin Toxin
PIB40_RS08975 (PIB40_08975) 2130962..2133065 - 2104 Protein_1730 DUF262 domain-containing protein -
PIB40_RS08980 (PIB40_08980) 2133155..2133796 - 642 WP_007052627.1 GNAT family N-acetyltransferase -
PIB40_RS08985 (PIB40_08985) 2133836..2134561 - 726 WP_007056206.1 response regulator transcription factor -
PIB40_RS08990 (PIB40_08990) 2134596..2135828 - 1233 WP_217061708.1 histidine kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 2057656..2154002 96346


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(9-146)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(6-61)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 18597.78 Da        Isoelectric Point: 6.2348

>T268628 WP_271710385.1 NZ_CP116390:2130421-2130912 [Bifidobacterium longum]
MRQSKQVSILCDTNILIYYMLCTPRFIKDVMKLFERCVEREVKLSCASLSLKDMFYITPERFKERFMNDESMVVATTAKL
ILPEVAWSGISKLKELMTIVPIGAEECELAQSLRHAHNDFEDDFIIAAAQQSGATYVVTYDKKLAKHFPEYCKTPAEIVA
ALA

Download         Length: 492 bp

Antitoxin


Download         Length: 131 a.a.        Molecular weight: 15147.29 Da        Isoelectric Point: 5.8624

>AT268628 WP_007057212.1 NZ_CP116390:2130032-2130424 [Bifidobacterium longum]
MTMVQMNVRIDAKLKNEVEEVLKGKGVSVSDVIRSLWLYIADRKEVPALETTAEEQAREAEKQRKLKLIREGAGYVHKEL
VKAGLISEDTDLMEGLTYKQFRDEIADERLKEYRHQSDYARYLEKERSLS

Download         Length: 393 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB F8APN1

References