Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 1453800..1455352 Replicon chromosome
Accession NZ_CP116384
Organism Vibrio sp. SCSIO 43137

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag PK654_RS22420 Protein ID WP_271699722.1
Coordinates 1453800..1455107 (-) Length 436 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag PK654_RS22425 Protein ID WP_271699723.1
Coordinates 1455107..1455352 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PK654_RS22390 (PK654_22390) 1449142..1450080 - 939 WP_271699711.1 tripartite tricarboxylate transporter substrate binding protein -
PK654_RS22395 (PK654_22395) 1450123..1450608 - 486 WP_271699713.1 universal stress protein -
PK654_RS22400 (PK654_22400) 1450789..1452093 + 1305 WP_271699715.1 FAD-binding oxidoreductase -
PK654_RS22405 (PK654_22405) 1452109..1452471 + 363 WP_271699716.1 cupin domain-containing protein -
PK654_RS22410 (PK654_22410) 1452638..1453021 + 384 WP_271699718.1 DUF2784 domain-containing protein -
PK654_RS22415 (PK654_22415) 1453018..1453773 + 756 WP_271699720.1 alpha/beta hydrolase -
PK654_RS22420 (PK654_22420) 1453800..1455107 - 1308 WP_271699722.1 type II toxin-antitoxin system HipA family toxin Toxin
PK654_RS22425 (PK654_22425) 1455107..1455352 - 246 WP_271699723.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
PK654_RS22430 (PK654_22430) 1455490..1456425 - 936 WP_271699724.1 LysR family transcriptional regulator -
PK654_RS22435 (PK654_22435) 1456507..1457139 - 633 WP_271699725.1 LysE family translocator -
PK654_RS22440 (PK654_22440) 1457189..1457440 - 252 WP_271700746.1 helix-turn-helix domain-containing protein -
PK654_RS22445 (PK654_22445) 1457597..1458049 - 453 WP_271699726.1 AraC family ligand binding domain-containing protein -
PK654_RS22450 (PK654_22450) 1458285..1458938 + 654 WP_271699727.1 transporter substrate-binding domain-containing protein -
PK654_RS22455 (PK654_22455) 1459076..1459789 - 714 WP_271699729.1 hexitol phosphatase HxpB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-60)


Sequences

Toxin        


Download         Length: 436 a.a.        Molecular weight: 49391.00 Da        Isoelectric Point: 6.8467

>T268625 WP_271699722.1 NZ_CP116384:c1455107-1453800 [Vibrio sp. SCSIO 43137]
MQELIAYMNGELVGRLKKQSNGAHSFQYDSDWITNSKARPLSLSLKLQLPRINSDAVINYFDNLLPDAPKVRERIVTRYK
ASSIQPFDLLKEVGKDSVGAITLLPPDKPYKEEPISYKVLDEDKLENVLLAYKSEIPLGMLEEEEDFRISVAGVQEKTAL
LRFNDQWCIPEGNTPTTHIIKLPIGEIQQAHATLDLTDSVENEYLCIELARELGFDVPEIEMIQVKSVKALAVERFDRRW
NRDRTKVLRLPQEDICQVYGKPPSIKYEFQGGPGIAEIMKLLMGSSNALDDQYNFMKFQVFQWAIGATDGHAKNYSIYIE
KGGSYRLTPFYDILSAYVVLGGKGLNIRKLKLAMGLKATKGKKYEINKIYAHHFLDTAKSVGFNQDKMQIILDDIQVDLP
EAIERVRGRLPKDFPDHVAEAIFGNSLKMVKKLAM

Download         Length: 1308 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 9314.51 Da        Isoelectric Point: 4.9622

>AT268625 WP_271699723.1 NZ_CP116384:c1455352-1455107 [Vibrio sp. SCSIO 43137]
MIYSPKQLADRILLIRQQNNWSQSELAKKVGIKQATISNFENNPSRTTLATFFKLLQAMDLVLTVDEKSQNQTSTPDDED
W

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References