Detailed information of TA system TA268624

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): sanaTA/AbiEii-DUF6088
• Location: 1218321..1219663
• Replicon: chromosome
• Accession: NZ_CP116384
• Organism: Vibrio sp. SCSIO 43137

Toxin (Protein)

• Gene name: sanaT
• Uniprot ID: -
• Locus tag: PK654_RS21385
• Protein ID: WP_271700741.1
• Coordinates: 1218728..1219663 (+)
• Length: 312 a.a.

Antitoxin (Protein)

• Gene name: sanaA
• Uniprot ID: -
• Locus tag: PK654_RS21380
• Protein ID: WP_271699448.1
• Coordinates: 1218321..1218725 (+)
• Length: 135 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PK654_RS21370 (PK654_21370)	1213664..1215715	-	2052	WP_271699444.1	methyl-accepting chemotaxis protein	-
PK654_RS21375 (PK654_21375)	1216448..1217818	+	1371	WP_271699446.1	YjiH family protein	-
PK654_RS21380 (PK654_21380)	1218321..1218725	+	405	WP_271699448.1	DUF6088 family protein	Antitoxin
PK654_RS21385 (PK654_21385)	1218728..1219663	+	936	WP_271700741.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
PK654_RS21390 (PK654_21390)	1220237..1220740	+	504	WP_271699449.1	hypothetical protein	-
PK654_RS21395 (PK654_21395)	1220815..1221621	+	807	WP_271699450.1	GIY-YIG nuclease family protein	-
PK654_RS21400 (PK654_21400)	1221648..1221956	+	309	WP_271699451.1	hypothetical protein	-
PK654_RS21405 (PK654_21405)	1222140..1223525	-	1386	WP_271699452.1	NCS2 family permease	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1212236..1213609	1373

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (38-300)

Antitoxin

• Protein of unknown function DUF6088 (7-130)

Sequences

Toxin

Protein

• Length: 312 a.a.
• Molecular weight: 35877.02 Da
• Isoelectric Point: 6.0595

>T268624 WP_271700741.1 NZ_CP116384:1218728-1219663 [Vibrio sp. SCSIO 43137]
IPKLKKQFLEVSDAIELGNPSITEKDYWVVSLLAMLESVESEHHQLVFSGGTALAKSNIKILRMSEDVDIKLIPNQEFLN
KGTGAKRKARKALVENLIARLVDHAYLKYSKRTVRDSYRYVEIEIEYPQQYHQAPCLRPYIKLELIETIEFQGVEPRSIS
SLVAQSYNQPAEVNAMSCISIDLTLVEKVLSMLRRTMSVKRNPQRKDDETLVRHIYDVHCINAQHTIDIGALKPIFDTVL
EEDKARYGNQHQDFVADPRNELKLGLEELETNEKFRERFEAFVAPMVYSTEPHDFDTCFTSFKNISEQLIN

Nucleotide

• Length: 936 bp

Antitoxin

Protein

• Length: 135 a.a.
• Molecular weight: 15538.94 Da
• Isoelectric Point: 10.6689

>AT268624 WP_271699448.1 NZ_CP116384:1218321-1218725 [Vibrio sp. SCSIO 43137]
MTATDRIYQKIKRSRRYVFERKDFDNYASYDQIGRVLKQLVDKGVLMKIGYGLYTKSTINSLTNKPMPTNPGGTDAIMRE
VLKMRGVDFELDAMSLKSLNGQSTQIPASIRYKWNSKYFNRSLKVGNRVLNERQ

Nucleotide

• Length: 405 bp