Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | PP_4151-4152/excise(antitoxin) |
| Location | 1286437..1287401 | Replicon | chromosome |
| Accession | NZ_CP116383 | ||
| Organism | Vibrio sp. SCSIO 43137 | ||
Toxin (Protein)
| Gene name | PP_4152 | Uniprot ID | - |
| Locus tag | PK654_RS06060 | Protein ID | WP_271698303.1 |
| Coordinates | 1286889..1287401 (+) | Length | 171 a.a. |
Antitoxin (Protein)
| Gene name | PP_4151 | Uniprot ID | - |
| Locus tag | PK654_RS06055 | Protein ID | WP_271698302.1 |
| Coordinates | 1286437..1286889 (+) | Length | 151 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PK654_RS06030 (PK654_06030) | 1281546..1282067 | + | 522 | WP_271698298.1 | rhodanese-like domain-containing protein | - |
| PK654_RS06035 (PK654_06035) | 1282069..1282947 | - | 879 | WP_271698299.1 | sensor domain-containing diguanylate cyclase | - |
| PK654_RS06040 (PK654_06040) | 1283009..1284628 | - | 1620 | Protein_1152 | ATP-binding cassette domain-containing protein | - |
| PK654_RS06045 (PK654_06045) | 1284971..1285735 | + | 765 | WP_271698300.1 | GNAT family N-acetyltransferase | - |
| PK654_RS06050 (PK654_06050) | 1285759..1286229 | - | 471 | WP_271698301.1 | GyrI-like domain-containing protein | - |
| PK654_RS06055 (PK654_06055) | 1286437..1286889 | + | 453 | WP_271698302.1 | excisionase family DNA-binding protein | Antitoxin |
| PK654_RS06060 (PK654_06060) | 1286889..1287401 | + | 513 | WP_271698303.1 | PIN domain-containing protein | Toxin |
| PK654_RS06065 (PK654_06065) | 1287454..1288026 | - | 573 | WP_271698304.1 | TetR/AcrR family transcriptional regulator | - |
| PK654_RS06070 (PK654_06070) | 1288149..1288712 | + | 564 | WP_271698305.1 | dihydrofolate reductase family protein | - |
| PK654_RS06075 (PK654_06075) | 1288880..1289755 | - | 876 | WP_271698306.1 | LysR family transcriptional regulator | - |
| PK654_RS06080 (PK654_06080) | 1289881..1290939 | + | 1059 | WP_271698307.1 | FAD-dependent oxidoreductase | - |
| PK654_RS06085 (PK654_06085) | 1290989..1291906 | - | 918 | WP_271698308.1 | LysR family transcriptional regulator | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 171 a.a. Molecular weight: 19406.60 Da Isoelectric Point: 5.7010
>T268620 WP_271698303.1 NZ_CP116383:1286889-1287401 [Vibrio sp. SCSIO 43137]
MGSYTVILDACVMYPAPLRSYLIYLSCTGLYRARWTKQIHDEWMRNVLKNNPDIDVKKLKRAKQLMDKSVPDCLIEDYES
LIAGIELPDMDDRHVVAAAVKGQAESIITFNLKDFPNDMLKAMDLNAIHPDEFLCDMFELNSGACVKAAQMQRRSLRNPP
MTVNEYLACL
MGSYTVILDACVMYPAPLRSYLIYLSCTGLYRARWTKQIHDEWMRNVLKNNPDIDVKKLKRAKQLMDKSVPDCLIEDYES
LIAGIELPDMDDRHVVAAAVKGQAESIITFNLKDFPNDMLKAMDLNAIHPDEFLCDMFELNSGACVKAAQMQRRSLRNPP
MTVNEYLACL
Download Length: 513 bp
Antitoxin
Download Length: 151 a.a. Molecular weight: 16199.51 Da Isoelectric Point: 5.2252
>AT268620 WP_271698302.1 NZ_CP116383:1286437-1286889 [Vibrio sp. SCSIO 43137]
MSVTTTLPSAEEMALAKLGSQELSAVVQANGEAQVIKVIDKSGNAHNVTLPASALTMMIEVLTQLGQGNSVNITPVHAEL
TSQEGADLLSVSRPTFIKLLDSGVIKYTRTGNRRKVAFADVMKYKKQREKESFASLDELSALDQELDMGY
MSVTTTLPSAEEMALAKLGSQELSAVVQANGEAQVIKVIDKSGNAHNVTLPASALTMMIEVLTQLGQGNSVNITPVHAEL
TSQEGADLLSVSRPTFIKLLDSGVIKYTRTGNRRKVAFADVMKYKKQREKESFASLDELSALDQELDMGY
Download Length: 453 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|
Antitoxin
| Source | ID | Structure |
|---|