Detailed information of TA system TA026862

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2842469..2843109
• Replicon: chromosome
• Accession: NC_017522
• Organism: Mycobacterium tuberculosis CCDC5180

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: G0TQ08
• Locus tag: CCDC5180_RS13395
• Protein ID: WP_003412970.1
• Coordinates: 2842469..2842888 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TQ09
• Locus tag: CCDC5180_RS13400
• Protein ID: WP_003412975.1
• Coordinates: 2842885..2843109 (-)
• Length: 75 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCDC5180_RS13370	2838059..2838781	-	723	WP_003412957.1	DUF1906 domain-containing protein	-
CCDC5180_RS13375	2839298..2839520	+	223	Protein_2602	type II toxin-antitoxin system VapB family antitoxin	-
CCDC5180_RS13380	2839517..2839918	+	402	WP_003412963.1	PIN domain-containing protein	-
CCDC5180_RS13385	2839953..2840873	-	921	WP_003412965.1	restriction endonuclease	-
CCDC5180_RS22635	2841214..2841459	-	246	WP_071854223.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
CCDC5180_RS13390	2841518..2842468	+	951	WP_003911916.1	Lsr2 family protein	-
CCDC5180_RS13395	2842469..2842888	-	420	WP_003412970.1	type II toxin-antitoxin system VapC family toxin	Toxin
CCDC5180_RS13400	2842885..2843109	-	225	WP_003412975.1	antitoxin VapB39	Antitoxin
CCDC5180_RS13405	2843140..2845983	-	2844	WP_003899363.1	aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme	-
CCDC5180_RS13410	2846055..2846456	-	402	WP_003412981.1	hypothetical protein	-
CCDC5180_RS13415	2846456..2846926	-	471	WP_003899364.1	transcription antitermination factor NusB	-
CCDC5180_RS13420	2846929..2847492	-	564	WP_003412989.1	elongation factor P	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (4-128)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 14732.70 Da
• Isoelectric Point: 6.7519

>T26862 WP_003412970.1 NC_017522:c2842888-2842469 [Mycobacterium tuberculosis CCDC5180]
VTALLDVNVLIALGWPNHVHHAAAQRWFTQFSSNGWATTPITEAGYVRISSNRSVMQVSTTPAIAIAQLAAMTSLAGHTF
WPDDVPLIVGSAGDRDAVSNHRRVTDCHLIALAARYGGRLVTFDAALADSASAGLVEVL

Nucleotide

• Length: 420 bp

>T26862 NC_017522:c2842888-2842469 [Mycobacterium tuberculosis CCDC5180]
GTGACGGCACTGCTCGATGTCAATGTGCTGATCGCGCTGGGCTGGCCGAATCACGTTCACCATGCGGCCGCGCAGCGATG
GTTCACGCAGTTCTCCTCGAATGGGTGGGCCACCACGCCGATCACCGAGGCAGGGTATGTCCGAATTTCAAGCAATCGCA
GTGTGATGCAGGTGTCGACCACGCCGGCTATCGCGATCGCTCAGTTGGCGGCGATGACTTCTCTTGCCGGGCACACGTTT
TGGCCTGACGATGTGCCACTGATCGTTGGGAGCGCCGGCGATCGCGATGCGGTGTCCAACCACCGTCGGGTCACCGACTG
CCATCTCATCGCCTTGGCCGCGCGCTACGGGGGCCGGTTGGTCACATTCGATGCCGCACTGGCCGATTCAGCATCCGCAG
GCCTCGTCGAGGTGTTGTAG

Antitoxin

Protein

• Length: 75 a.a.
• Molecular weight: 7993.94 Da
• Isoelectric Point: 4.0057

>AT26862 WP_003412975.1 NC_017522:c2843109-2842885 [Mycobacterium tuberculosis CCDC5180]
MRTTLQIDDDVLEDARSIARSEGKSVGAVISELARRSLRPVGIVEVDGFPVFDVPPDAPTVTSEDVVRALEDDV

Nucleotide

• Length: 225 bp

>AT26862 NC_017522:c2843109-2842885 [Mycobacterium tuberculosis CCDC5180]
ATGCGCACCACGTTGCAGATTGATGATGATGTTCTAGAAGATGCTCGTAGCATCGCGCGGTCGGAGGGCAAGTCAGTCGG
CGCGGTAATTTCTGAGTTGGCGCGTAGGTCGCTCCGTCCGGTTGGGATTGTCGAGGTTGACGGATTTCCGGTTTTTGATG
TTCCGCCGGATGCGCCGACGGTGACTTCCGAGGATGTCGTCCGCGCGCTCGAGGACGACGTGTGA

Structures

Toxin

• AlphaFold DB: G0TQ08

Antitoxin

• AlphaFold DB: G0TQ09