Detailed information of TA system TA268618

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1216668..1218375
• Replicon: chromosome
• Accession: NZ_CP116383
• Organism: Vibrio sp. SCSIO 43137

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: PK654_RS05765
• Protein ID: WP_271698811.1
• Coordinates: 1216668..1217591 (-)
• Length: 308 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: PK654_RS05770
• Protein ID: WP_271698253.1
• Coordinates: 1217575..1218375 (-)
• Length: 267 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
PK654_RS05745 (PK654_05745)	1212794..1214041	+	1248	WP_271698249.1	NupC/NupG family nucleoside CNT transporter	-
PK654_RS05750 (PK654_05750)	1214081..1214893	+	813	WP_271698250.1	outer membrane protein OmpK	-
PK654_RS05755 (PK654_05755)	1214995..1216167	+	1173	WP_271698251.1	methyl-accepting chemotaxis protein	-
PK654_RS05760 (PK654_05760)	1216143..1216388	+	246	WP_271698252.1	hypothetical protein	-
PK654_RS05765 (PK654_05765)	1216668..1217591	-	924	WP_271698811.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
PK654_RS05770 (PK654_05770)	1217575..1218375	-	801	WP_271698253.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
PK654_RS05775 (PK654_05775)	1218725..1219177	+	453	WP_271698254.1	type II secretion system protein	-
PK654_RS05780 (PK654_05780)	1219508..1220131	+	624	WP_271698255.1	bifunctional 4-hydroxy-2-oxoglutarate aldolase/2-dehydro-3-deoxy-phosphogluconate aldolase	-
PK654_RS05785 (PK654_05785)	1220245..1221123	+	879	WP_271698256.1	AEC family transporter	-
PK654_RS05790 (PK654_05790)	1221257..1222195	+	939	WP_271698257.1	DUF2860 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (13-276)

Antitoxin

• Transcriptional regulator, AbiEi 3 antitoxin, Type IV TA system (100-250)

Sequences

Toxin

Protein

• Length: 308 a.a.
• Molecular weight: 35105.45 Da
• Isoelectric Point: 6.5048

>T268618 WP_271698811.1 NZ_CP116383:c1217591-1216668 [Vibrio sp. SCSIO 43137]
MEREASYYKQVALLVRILPIVASEPAFALKGGTAINLFVRDLPRLSVDIDLTYLPKEPRDEALTNIRTALQRIAVQINKQ
PNTKAVVQDNKTDELRIIVTTSQATIKIEVSPVARGCLHKPQTLTVQESVEDEFGYAEIPVVSIPDLYGGKLCAAMDRQH
PRDLFDVLVLIKNEGISREIFVGFITYALGHPRPINELMTPNWRSLDKEFHIEFEGMTVSAVSLDELKQVRQQMIEALQV
HFTKRDHDFLLSFKQGNPDWTLFDYPDVAELPAVRWKLHNISRLAQNQTKHDEQLSKLKKVLDEWLK

Nucleotide

• Length: 924 bp

Antitoxin

Protein

• Length: 267 a.a.
• Molecular weight: 30244.24 Da
• Isoelectric Point: 9.0696

>AT268618 WP_271698253.1 NZ_CP116383:c1218375-1217575 [Vibrio sp. SCSIO 43137]
MNSKINWLVTHTSAGSLVLQPWLTENGISYSLAQRYTKSGWLKKLSAGVYYRPGATEEVKPDWVDAIQAIDQQLHLPVHL
AGLSSLNHQGLSHYLPLTEERVWVGSKNRQSLPKWFREFPEQNWFYSGSHKVPLLTERDFKTITIKGKELKASCPELAAY
EVIDAVGKQISFEHAAELFQGLVNLSPRKVQSILERSSSVQTNRVFLFLSHYHGHQWAKHLDETAIQLGSGKRQIVENGQ
FDQRYQITVPKGLSIKESHYYDGEGS

Nucleotide

• Length: 801 bp