Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4174290..4174947 Replicon chromosome
Accession NZ_CP116347
Organism Enterobacter ludwigii strain CM-TZ4

Toxin (Protein)


Gene name cptA Uniprot ID G8LDB6
Locus tag PHA72_RS20540 Protein ID WP_014171514.1
Coordinates 4174290..4174700 (-) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID G8LDB7
Locus tag PHA72_RS20545 Protein ID WP_003863437.1
Coordinates 4174681..4174947 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PHA72_RS20520 (PHA72_20515) 4170288..4172021 - 1734 WP_044866092.1 single-stranded-DNA-specific exonuclease RecJ -
PHA72_RS20525 (PHA72_20520) 4172027..4172740 - 714 WP_020883731.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
PHA72_RS20530 (PHA72_20525) 4172764..4173660 - 897 WP_050737268.1 site-specific tyrosine recombinase XerD -
PHA72_RS20535 (PHA72_20530) 4173762..4174283 + 522 WP_059306190.1 flavodoxin FldB -
PHA72_RS20540 (PHA72_20535) 4174290..4174700 - 411 WP_014171514.1 protein YgfX Toxin
PHA72_RS20545 (PHA72_20540) 4174681..4174947 - 267 WP_003863437.1 FAD assembly factor SdhE Antitoxin
PHA72_RS20550 (PHA72_20545) 4175242..4176222 + 981 WP_020883730.1 tRNA-modifying protein YgfZ -
PHA72_RS20555 (PHA72_20550) 4176333..4176992 - 660 WP_014171517.1 hemolysin III family protein -
PHA72_RS20560 (PHA72_20555) 4177259..4177990 + 732 WP_040018863.1 MurR/RpiR family transcriptional regulator -
PHA72_RS20565 (PHA72_20560) 4178107..4179540 + 1434 WP_020883728.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16217.15 Da        Isoelectric Point: 11.5020

>T268611 WP_014171514.1 NZ_CP116347:c4174700-4174290 [Enterobacter ludwigii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRIHARQGEIKLLMDSRLRWQGK
EWEILGMPWMIASGMMLRLRSVDSGRRQHLWLAADSMDSAEWRDLRRMLLQQLTQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10526.96 Da        Isoelectric Point: 4.8310

>AT268611 WP_003863437.1 NZ_CP116347:c4174947-4174681 [Enterobacter ludwigii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
QERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A839BUV6

Antitoxin

Source ID Structure
AlphaFold DB A0A837F8P5

References