Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) VapXD/-
Location 233..696 Replicon plasmid pCryptic
Accession NZ_CP116344
Organism Neisseria gonorrhoeae strain SE690.

Toxin (Protein)


Gene name VapD Uniprot ID Q51003
Locus tag PH604_RS11665 Protein ID WP_003690225.1
Coordinates 233..511 (-) Length 93 a.a.

Antitoxin (Protein)


Gene name VapX Uniprot ID Q51002
Locus tag PH604_RS11670 Protein ID WP_003690223.1
Coordinates 511..696 (-) Length 62 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH604_RS11660 (PH604_11695) 1..255 + 255 WP_003690227.1 Cryptic plasmid protein A -
PH604_RS11665 (PH604_11700) 233..511 - 279 WP_003690225.1 endoribonuclease VapD Toxin
PH604_RS11670 (PH604_11705) 511..696 - 186 WP_003690223.1 DUF5397 family protein Antitoxin
PH604_RS11675 (PH604_11710) 699..944 - 246 WP_003690221.1 hypothetical protein -
PH604_RS11680 (PH604_11715) 941..1183 - 243 WP_003690220.1 HTH domain-containing protein -
PH604_RS11685 (PH604_11720) 1187..2056 - 870 WP_003690219.1 replication initiation protein -
PH604_RS11690 (PH604_11725) 2442..2822 + 381 WP_014580441.1 MobC family plasmid mobilization relaxosome protein -
PH604_RS11695 (PH604_11730) 2807..3436 + 630 WP_003696452.1 relaxase/mobilization nuclease domain-containing protein -
PH604_RS11700 (PH604_11735) 3520..4161 + 642 WP_003690229.1 MbeB family mobilization protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..4207 4207


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Virulence-associated protein D / CRISPR associated protein Cas2

(1-86)

Antitoxin

Protein of unknown function DUF5397

(2-60)


Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10473.89 Da        Isoelectric Point: 6.9726

>T268604 WP_003690225.1 NZ_CP116344:c511-233 [Neisseria gonorrhoeae]
MYAISFDLVVADTAQNHPKGISQAYADIGYTLRKFGFTRIQGSLYTCQNEDMANLFSAINELKALPWFPSSVRDIRAFRI
EQWSDFTSLVKS

Download         Length: 279 bp

Antitoxin


Download         Length: 62 a.a.        Molecular weight: 6717.54 Da        Isoelectric Point: 4.2641

>AT268604 WP_003690223.1 NZ_CP116344:c696-511 [Neisseria gonorrhoeae]
MQTTIPTGSIRTFGDYGVMYIVGTPAEQLPDGDWLVNIELPESGEHTQYKLSHIVQDPKAA

Download         Length: 186 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7H5FJI5

Antitoxin

Source ID Structure
AlphaFold DB Q51002

References