Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | omega-epsilon-zeta/zeta(toxin) |
| Location | 26707..28358 | Replicon | plasmid pConj |
| Accession | NZ_CP116343 | ||
| Organism | Neisseria gonorrhoeae strain SE690. | ||
Toxin (Protein)
| Gene name | ng_zeta1 | Uniprot ID | D5K9G7 |
| Locus tag | PH604_RS11570 | Protein ID | WP_003701905.1 |
| Coordinates | 26707..27912 (+) | Length | 402 a.a. |
Antitoxin (Protein)
| Gene name | ng_epsilon1 | Uniprot ID | D5K9G8 |
| Locus tag | PH604_RS11575 | Protein ID | WP_003701903.1 |
| Coordinates | 27927..28358 (+) | Length | 144 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| PH604_RS11545 (PH604_11525) | 23620..23736 | - | 117 | WP_001791010.1 | tetracycline resistance determinant leader peptide | - |
| PH604_RS11550 (PH604_11530) | 24124..24645 | + | 522 | WP_003701911.1 | hypothetical protein | - |
| PH604_RS11555 (PH604_11535) | 25022..25276 | + | 255 | WP_013085578.1 | hypothetical protein | - |
| PH604_RS11560 (PH604_11540) | 25273..26481 | + | 1209 | WP_003701908.1 | zeta toxin family protein | - |
| PH604_RS11565 (PH604_11545) | 26515..26700 | + | 186 | WP_003701907.1 | hypothetical protein | - |
| PH604_RS11570 (PH604_11550) | 26707..27912 | + | 1206 | WP_003701905.1 | toxin | Toxin |
| PH604_RS11575 (PH604_11555) | 27927..28358 | + | 432 | WP_003701903.1 | hypothetical protein | Antitoxin |
| PH604_RS11580 (PH604_11560) | 28410..28964 | + | 555 | WP_003701901.1 | recombinase family protein | - |
| PH604_RS11585 (PH604_11565) | 29074..29364 | - | 291 | WP_003701899.1 | virulence factor | - |
| PH604_RS11590 (PH604_11570) | 29467..30066 | - | 600 | WP_003701898.1 | TrbN protein | - |
| PH604_RS11595 (PH604_11575) | 30066..30638 | - | 573 | WP_014580059.1 | TrbM/KikA/MpfK family conjugal transfer protein | - |
| PH604_RS11600 (PH604_11580) | 30631..32238 | - | 1608 | WP_228547153.1 | P-type conjugative transfer protein TrbL | - |
| PH604_RS11605 (PH604_11585) | 32473..33249 | - | 777 | WP_003701891.1 | P-type conjugative transfer protein TrbJ | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | tet(M) | - | 1..42004 | 42004 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 402 a.a. Molecular weight: 44675.53 Da Isoelectric Point: 7.7756
>T268603 WP_003701905.1 NZ_CP116343:26707-27912 [Neisseria gonorrhoeae]
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGRGASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGRGASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R
Download Length: 1206 bp
Antitoxin
Download Length: 144 a.a. Molecular weight: 15927.05 Da Isoelectric Point: 4.4211
>AT268603 WP_003701903.1 NZ_CP116343:27927-28358 [Neisseria gonorrhoeae]
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ
Download Length: 432 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|