Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) omega-epsilon-zeta/zeta(toxin)
Location 26707..28358 Replicon plasmid pConj
Accession NZ_CP116343
Organism Neisseria gonorrhoeae strain SE690.

Toxin (Protein)


Gene name ng_zeta1 Uniprot ID D5K9G7
Locus tag PH604_RS11570 Protein ID WP_003701905.1
Coordinates 26707..27912 (+) Length 402 a.a.

Antitoxin (Protein)


Gene name ng_epsilon1 Uniprot ID D5K9G8
Locus tag PH604_RS11575 Protein ID WP_003701903.1
Coordinates 27927..28358 (+) Length 144 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH604_RS11545 (PH604_11525) 23620..23736 - 117 WP_001791010.1 tetracycline resistance determinant leader peptide -
PH604_RS11550 (PH604_11530) 24124..24645 + 522 WP_003701911.1 hypothetical protein -
PH604_RS11555 (PH604_11535) 25022..25276 + 255 WP_013085578.1 hypothetical protein -
PH604_RS11560 (PH604_11540) 25273..26481 + 1209 WP_003701908.1 zeta toxin family protein -
PH604_RS11565 (PH604_11545) 26515..26700 + 186 WP_003701907.1 hypothetical protein -
PH604_RS11570 (PH604_11550) 26707..27912 + 1206 WP_003701905.1 toxin Toxin
PH604_RS11575 (PH604_11555) 27927..28358 + 432 WP_003701903.1 hypothetical protein Antitoxin
PH604_RS11580 (PH604_11560) 28410..28964 + 555 WP_003701901.1 recombinase family protein -
PH604_RS11585 (PH604_11565) 29074..29364 - 291 WP_003701899.1 virulence factor -
PH604_RS11590 (PH604_11570) 29467..30066 - 600 WP_003701898.1 TrbN protein -
PH604_RS11595 (PH604_11575) 30066..30638 - 573 WP_014580059.1 TrbM/KikA/MpfK family conjugal transfer protein -
PH604_RS11600 (PH604_11580) 30631..32238 - 1608 WP_228547153.1 P-type conjugative transfer protein TrbL -
PH604_RS11605 (PH604_11585) 32473..33249 - 777 WP_003701891.1 P-type conjugative transfer protein TrbJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid tet(M) - 1..42004 42004


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

KfrB domain

(284-343)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 402 a.a.        Molecular weight: 44675.53 Da        Isoelectric Point: 7.7756

>T268603 WP_003701905.1 NZ_CP116343:26707-27912 [Neisseria gonorrhoeae]
MVKLSSDINLRDFGNNEYLSSVQDEAIRFATEQTDEILSLYSQHADTEGGRYVCADTFKELFPAFENKEDRATVNNAIHN
SAAVLSSTQFDEVLKRDEPQKKEVIFVTGIPGSGKTSTVKNMMMQDTTKLLFEGQLARPQSAFRKIEQCLERNLEVTIVA
VSMRAERASDNTYKRFNEYGRGASIGIMADIQANLPDGLKQIRDKFGDAVKIVGINQDRNSEFIDKFDDVIKMLSLGSQE
QILGRLAEKIQSDFDSGKISRECFNQAKGSMDLESVFAKKEYSQQRVVTNSKGVTLETKSANELWSKVEQIPVTGMKAGI
YLLGQAKKAETGQTYSGEIIYKDAAAVFQKTKNGLVRHNATHNEERLAKLVEIGQNVSIGSNKGKLIVKSLEYSAKKSIS
R

Download         Length: 1206 bp

Antitoxin


Download         Length: 144 a.a.        Molecular weight: 15927.05 Da        Isoelectric Point: 4.4211

>AT268603 WP_003701903.1 NZ_CP116343:27927-28358 [Neisseria gonorrhoeae]
MKEKMRLITEISLIIRELSYSRRGYRPESYAAALDNLTIIGDLADILHNIEAATGNPFVQRMVDEKLRKFVTDFPAYKVR
LSPFLNGCPHDLSLGAESLGKGESIADALAVPPEEVDIADIEFDRVLIEDDRWTGAYDGGNAQ

Download         Length: 432 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6EPI
PDB 6EPG
PDB 6EPH

Antitoxin

Source ID Structure
AlphaFold DB D5K9G8

References