Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-StbC
Location 889604..890259 Replicon chromosome
Accession NZ_CP116342
Organism Neisseria gonorrhoeae strain SE690.

Toxin (Protein)


Gene name vapC Uniprot ID Q5F882
Locus tag PH604_RS04585 Protein ID WP_003691083.1
Coordinates 889604..890023 (-) Length 140 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID Q5F881
Locus tag PH604_RS04590 Protein ID WP_003688410.1
Coordinates 890023..890259 (-) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PH604_RS04565 (PH604_04550) 884838..886379 - 1542 WP_003701286.1 MDR family MFS transporter -
PH604_RS04570 (PH604_04555) 886527..887306 + 780 WP_003688416.1 (Fe-S)-binding protein -
PH604_RS04575 (PH604_04560) 887303..888004 + 702 WP_003688414.1 lactate utilization protein C -
PH604_RS04580 (PH604_04565) 888001..889455 + 1455 WP_003688412.1 LutB/LldF family L-lactate oxidation iron-sulfur protein -
PH604_RS04585 (PH604_04570) 889604..890023 - 420 WP_003691083.1 type II toxin-antitoxin system toxin FitB Toxin
PH604_RS04590 (PH604_04575) 890023..890259 - 237 WP_003688410.1 type II toxin-antitoxin system antitoxin FitA Antitoxin
PH604_RS04595 (PH604_04580) 890707..891285 - 579 WP_003688041.1 IS3 family transposase -
PH604_RS04600 (PH604_04585) 891290..891691 - 402 WP_020996834.1 helix-turn-helix domain-containing protein -
PH604_RS04605 (PH604_04590) 891930..892316 + 387 Protein_903 IS110 family transposase -
PH604_RS04610 (PH604_04595) 892699..893589 - 891 WP_272656726.1 succinate--CoA ligase subunit alpha -
PH604_RS04615 (PH604_04600) 893600..894766 - 1167 WP_003688408.1 ADP-forming succinate--CoA ligase subunit beta -
PH604_RS04620 (PH604_04605) 894838..895125 - 288 WP_003688407.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 140 a.a.        Molecular weight: 15306.65 Da        Isoelectric Point: 6.0798

>T268601 WP_003691083.1 NZ_CP116342:c890023-889604 [Neisseria gonorrhoeae]
MILLDTNVISEPLRPQPNERVVAWLDSLILEDVYLSAITVAELRLGVALLLNGKKKNVLHERLEQSILPLFAGRILPFDE
PVAAIYAQIRSYAKTHGKEIAAADGYIAATAKQHSLTVATRDTGSFFAADVAVFNPWHD

Download         Length: 420 bp

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8433.57 Da        Isoelectric Point: 7.0129

>AT268601 WP_003688410.1 NZ_CP116342:c890259-890023 [Neisseria gonorrhoeae]
MASVVIRNLSEATHNAIKFRARAAGRSTEAEIRLILDNIAKAQQTVRLGSMLASIGQEIGGVELEDVRGRNTDNEVSL

Download         Length: 237 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O

Antitoxin

Source ID Structure
PDB 2H1C
PDB 2BSQ
PDB 2H1O
AlphaFold DB Q5F881

References