Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/-
Location 2394615..2395144 Replicon chromosome
Accession NC_017522
Organism Mycobacterium tuberculosis CCDC5180

Toxin (Protein)


Gene name parE Uniprot ID G0TMR4
Locus tag CCDC5180_RS11300 Protein ID WP_003411124.1
Coordinates 2394615..2394932 (-) Length 106 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID P9WJ74
Locus tag CCDC5180_RS11305 Protein ID WP_003411127.1
Coordinates 2394929..2395144 (-) Length 72 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
CCDC5180_RS11270 2389752..2390828 + 1077 WP_003411110.1 hypothetical protein -
CCDC5180_RS11275 2390825..2391106 + 282 WP_003411112.1 hypothetical protein -
CCDC5180_RS11280 2391142..2392215 + 1074 WP_003901338.1 quinone-dependent dihydroorotate dehydrogenase -
CCDC5180_RS11285 2392220..2392750 - 531 WP_003411119.1 YbhB/YbcL family Raf kinase inhibitor-like protein -
CCDC5180_RS11290 2392798..2394144 - 1347 WP_003411121.1 M20/M25/M40 family metallo-hydrolase -
CCDC5180_RS11300 2394615..2394932 - 318 WP_003411124.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
CCDC5180_RS11305 2394929..2395144 - 216 WP_003411127.1 antitoxin ParD2 Antitoxin
CCDC5180_RS11310 2395399..2396457 + 1059 WP_003411129.1 hypothetical protein -
CCDC5180_RS11315 2396587..2396943 - 357 WP_003411130.1 hypothetical protein -
CCDC5180_RS11320 2397038..2397820 - 783 WP_003411131.1 cell wall synthesis protein Wag31 -
CCDC5180_RS11325 2398088..2398378 - 291 WP_003900476.1 YggT family protein -
CCDC5180_RS11330 2398540..2399196 - 657 WP_003411133.1 cell division protein SepF -
CCDC5180_RS11335 2399258..2400037 - 780 WP_015575160.1 YggS family pyridoxal phosphate-dependent enzyme -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-92)

Antitoxin

Conserved hypothetical protein CHP02574, addiction module

(11-69)


Sequences

Toxin        


Download         Length: 106 a.a.        Molecular weight: 12312.88 Da        Isoelectric Point: 6.4831

>T26860 WP_003411124.1 NC_017522:c2394932-2394615 [Mycobacterium tuberculosis CCDC5180]
MTRRLRVHNGVEDDLFEAFSYYADAAPDQIDRLYNLFVDAVTKRIPQAPNAFAPLFKHYRHIYLRPFRYYVAYRTTDEAI
DILAVRHGMENPNAVEAEISGRTFE

Download         Length: 318 bp

>T26860 NC_017522:c2394932-2394615 [Mycobacterium tuberculosis CCDC5180]
ATGACGCGCAGGCTGCGCGTCCATAACGGGGTTGAAGACGACCTATTCGAGGCGTTTTCCTACTACGCGGACGCGGCGCC
AGATCAGATCGATCGGCTTTACAACTTGTTTGTCGATGCCGTGACGAAGCGGATTCCGCAGGCTCCGAACGCGTTTGCGC
CGTTATTCAAGCACTATCGACACATCTACCTCCGGCCCTTCAGGTACTACGTTGCCTATCGGACGACCGACGAGGCTATC
GACATACTGGCTGTTCGGCACGGAATGGAGAACCCGAACGCGGTCGAGGCTGAGATCTCTGGCCGCACCTTCGAGTGA

Antitoxin


Download         Length: 72 a.a.        Molecular weight: 7880.70 Da        Isoelectric Point: 4.4055

>AT26860 WP_003411127.1 NC_017522:c2395144-2394929 [Mycobacterium tuberculosis CCDC5180]
VVVNRALLASVDALSRDEQIELVEHINGNLAEGMHISEANQALIEARANDTDDAHWSTIDDFDKRIRARLG

Download         Length: 216 bp

>AT26860 NC_017522:c2395144-2394929 [Mycobacterium tuberculosis CCDC5180]
GTGGTGGTCAACCGGGCATTGCTGGCGAGCGTCGACGCACTGTCGCGTGATGAGCAGATTGAGCTCGTCGAGCACATCAA
CGGAAACCTAGCCGAGGGCATGCATATCAGCGAGGCCAACCAGGCGCTCATCGAAGCGCGGGCCAATGACACCGACGATG
CTCATTGGTCCACCATTGATGACTTCGACAAGCGGATCCGCGCCCGGCTCGGATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB G0TMR4

Antitoxin

Source ID Structure
AlphaFold DB A0A7U4FAJ4

References