Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /SpoIISA(toxin)
Location 1776823..1777801 Replicon chromosome
Accession NZ_CP116325
Organism Bacillus thuringiensis strain BLB1

Toxin (Protein)


Gene name spoIISA Uniprot ID W8Y388
Locus tag PJW01_RS09455 Protein ID WP_000624977.1
Coordinates 1776823..1777560 (+) Length 246 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID W8YZL5
Locus tag PJW01_RS09460 Protein ID WP_000237818.1
Coordinates 1777673..1777801 (+) Length 43 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PJW01_RS09435 (PJW01_09435) 1772466..1773248 + 783 WP_000381800.1 class I SAM-dependent methyltransferase -
PJW01_RS09440 (PJW01_09440) 1773406..1775091 - 1686 WP_003284281.1 alpha-keto acid decarboxylase family protein -
PJW01_RS09445 (PJW01_09445) 1775199..1775681 + 483 WP_000191888.1 MarR family winged helix-turn-helix transcriptional regulator -
PJW01_RS09450 (PJW01_09450) 1775848..1776585 + 738 WP_000594152.1 2,3-diphosphoglycerate-dependent phosphoglycerate mutase -
PJW01_RS09455 (PJW01_09455) 1776823..1777560 + 738 WP_000624977.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
PJW01_RS09460 (PJW01_09460) 1777673..1777801 + 129 WP_000237818.1 hypothetical protein Antitoxin
PJW01_RS09465 (PJW01_09465) 1777874..1778050 + 177 WP_000852629.1 stage II sporulation protein SB -
PJW01_RS09470 (PJW01_09470) 1778069..1778458 - 390 WP_000713866.1 YxeA family protein -
PJW01_RS09475 (PJW01_09475) 1778670..1780139 + 1470 WP_000287515.1 beta-Ala-His dipeptidase -
PJW01_RS09480 (PJW01_09480) 1780385..1781194 + 810 WP_000678509.1 papain-like cysteine protease family protein -
PJW01_RS09485 (PJW01_09485) 1781220..1781822 + 603 WP_000517260.1 hypothetical protein -
PJW01_RS09490 (PJW01_09490) 1782062..1782313 - 252 WP_000827560.1 LuxR C-terminal-related transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(10-243)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 246 a.a.        Molecular weight: 28307.03 Da        Isoelectric Point: 8.2998

>T268593 WP_000624977.1 NZ_CP116325:1776823-1777560 [Bacillus thuringiensis]
MISNIRIGLFVLAIVFVVLVFFYWKNEELYEEKKQRIRKTWYGLFIISVTVYFMIKGIDLTLWKNLLMFTAMVIFVDIAF
ILTPNISEIWGAKFSDIGKTVQSIKRSLIASKARGEIYTTIIQNVNPAVFGTMEWHTEEEYTKSLNAFLDSYGEKIGAKI
VVFEAAKELNTNFRGIRSQFSIIVPLEHIEQLNEQKAVQVENVGIIPAKIVSDVFIVIDGKKNNLQDRDFENVYNLTIHH
SYFSK

Download         Length: 738 bp

Antitoxin


Download         Length: 43 a.a.        Molecular weight: 5011.40 Da        Isoelectric Point: 3.9150

>AT268593 WP_000237818.1 NZ_CP116325:1777673-1777801 [Bacillus thuringiensis]
VVKDYDNDFFKEDNEDTTDFSLIKGDTLQQVEELEEELKRKS

Download         Length: 129 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB W8Y388

Antitoxin

Source ID Structure
AlphaFold DB W8YZL5

References