Detailed information of TA system TA026859

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/PIN(toxin)
• Location: 2356453..2357148
• Replicon: chromosome
• Accession: NC_017522
• Organism: Mycobacterium tuberculosis CCDC5180

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: CCDC5180_RS11075
• Protein ID: WP_003905754.1
• Coordinates: 2356453..2356887 (-)
• Length: 145 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: G0TMN0
• Locus tag: CCDC5180_RS11080
• Protein ID: WP_003410814.1
• Coordinates: 2356894..2357148 (-)
• Length: 85 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
CCDC5180_RS11065	2352607..2355648	+	3042	WP_003899171.1	DEAD/DEAH box helicase	-
CCDC5180_RS11070	2355641..2356474	+	834	WP_003899172.1	SWIM zinc finger family protein	-
CCDC5180_RS11075	2356453..2356887	-	435	WP_003905754.1	type II toxin-antitoxin system VapC family toxin	Toxin
CCDC5180_RS11080	2356894..2357148	-	255	WP_003410814.1	antitoxin	Antitoxin
CCDC5180_RS11085	2357164..2357421	-	258	WP_003410816.1	hypothetical protein	-
CCDC5180_RS11095	2357955..2359216	+	1262	WP_087902221.1	IS3-like element IS987 family transposase	-
CCDC5180_RS11100	2359726..2360022	+	297	WP_003410820.1	PE family protein	-
CCDC5180_RS11105	2360078..2360809	+	732	WP_003900467.1	PPE family protein	-
CCDC5180_RS11110	2361349..2362095	-	747	WP_003901330.1	proteasome subunit alpha	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain toxin (1-142)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 145 a.a.
• Molecular weight: 15632.05 Da
• Isoelectric Point: 7.4681

>T26859 WP_003905754.1 NC_017522:c2356887-2356453 [Mycobacterium tuberculosis CCDC5180]
MKIVDANVLLYAVNTASEHHKPSLRWLDGALSGADRVGFAWVPLLAFVRLATKVGLFPRPLPREAAITQVADWLAAPSAV
LVNPTVRHADILARMLTYVGTGANLVNDAHLAALAVEHRASIVSYDSDFGRFEGVRWDQPPALL

Nucleotide

• Length: 435 bp

>T26859 NC_017522:c2356887-2356453 [Mycobacterium tuberculosis CCDC5180]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCGCAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA

Antitoxin

Protein

• Length: 85 a.a.
• Molecular weight: 9417.57 Da
• Isoelectric Point: 8.9912

>AT26859 WP_003410814.1 NC_017522:c2357148-2356894 [Mycobacterium tuberculosis CCDC5180]
MRTTVTLDDDVEQLVRRRMAERQVSFKKALNDAIRDGASGRPAPSHFSTRTADLGVPAVNLDRALQLAADLEDEELVRRQ
RRGS

Nucleotide

• Length: 255 bp

>AT26859 NC_017522:c2357148-2356894 [Mycobacterium tuberculosis CCDC5180]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG

Structures

Antitoxin

• AlphaFold DB: G0TMN0