Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/FR47-DUF1778
Location 11251..12047 Replicon plasmid pGEV872.3
Accession NZ_CP116308
Organism Xanthomonas perforans strain GEV872

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A6L9VEW6
Locus tag PJW04_RS22535 Protein ID WP_033836093.1
Coordinates 11538..12047 (+) Length 170 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A6P0G6J6
Locus tag PJW04_RS22530 Protein ID WP_017154722.1
Coordinates 11251..11541 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PJW04_RS22490 (PJW04_22490) 6496..6741 - 246 WP_046932153.1 hypothetical protein -
PJW04_RS22495 (PJW04_22495) 7025..8452 - 1428 WP_046932154.1 hypothetical protein -
PJW04_RS22500 (PJW04_22500) 8652..8987 - 336 WP_040279228.1 ParC family partition-associated protein -
PJW04_RS22505 (PJW04_22505) 9093..9317 - 225 WP_040279226.1 plasmid partition protein ParG -
PJW04_RS22510 (PJW04_22510) 9338..9967 - 630 WP_017154718.1 ParA family partition ATPase -
PJW04_RS22515 (PJW04_22515) 10045..10602 - 558 WP_017154719.1 recombinase family protein -
PJW04_RS22520 (PJW04_22520) 10605..10742 - 138 WP_017154720.1 hypothetical protein -
PJW04_RS22525 (PJW04_22525) 10771..10980 - 210 WP_228996802.1 hypothetical protein -
PJW04_RS22530 (PJW04_22530) 11251..11541 + 291 WP_017154722.1 DUF1778 domain-containing protein Antitoxin
PJW04_RS22535 (PJW04_22535) 11538..12047 + 510 WP_033836093.1 GNAT family N-acetyltransferase Toxin
PJW04_RS22540 (PJW04_22540) 12044..12310 + 267 WP_033836092.1 hypothetical protein -
PJW04_RS22545 (PJW04_22545) 12605..13093 - 489 WP_228996803.1 hypothetical protein -
PJW04_RS22550 (PJW04_22550) 13096..13356 - 261 WP_228996804.1 hypothetical protein -
PJW04_RS22555 (PJW04_22555) 13353..15791 - 2439 WP_046932161.1 relaxase/mobilization nuclease domain-containing protein -
PJW04_RS22560 (PJW04_22560) 15781..16176 - 396 WP_017154702.1 plasmid mobilization protein MobA -
PJW04_RS22565 (PJW04_22565) 16575..16880 + 306 WP_017154703.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..18815 18815
- flank IS/Tn - - 10045..10602 557


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(42-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 170 a.a.        Molecular weight: 18189.82 Da        Isoelectric Point: 8.0537

>T268586 WP_033836093.1 NZ_CP116308:11538-12047 [Xanthomonas perforans]
MKVSAPEPLAAHHDIEAFDSGVDSLDQWLKRRALKNQATGASRTFVACDDGRVVAYYALASSGVTVDAAPGRFRRNMPDP
IPVVVLGRLAVDQSQQGRGLGRALVKDAGQRIVQAADTIGIRGVLVHALSADAKAFYERIGFEPSPLDPMMLLVTLDDLK
ASLEPQARR

Download         Length: 510 bp

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10721.29 Da        Isoelectric Point: 10.2633

>AT268586 WP_017154722.1 NZ_CP116308:11251-11541 [Xanthomonas perforans]
MPTMSTAPSKRETLNIRIKPEERSLIDRAAKARGKNRTDFVLEAARSAAEEALLDQTIISASPDAYAAFLARLDMPPQPN
ERLRKTMQTPAPWEKA

Download         Length: 291 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A6L9VEW6

Antitoxin

Source ID Structure
AlphaFold DB A0A6P0G6J6

References