Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 185944..186464 Replicon plasmid pPSbnut
Accession NZ_CP116286
Organism MAG: Pantoea stewartii isolate RON18713

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag LZT29_RS21065 Protein ID WP_054633990.1
Coordinates 185944..186243 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H3RK39
Locus tag LZT29_RS21070 Protein ID WP_006121899.1
Coordinates 186246..186464 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LZT29_RS21050 (LZT29_04366) 182679..183683 + 1005 WP_054633987.1 decarboxylating 6-phosphogluconate dehydrogenase -
LZT29_RS21055 (LZT29_04367) 183701..185071 + 1371 WP_283788997.1 glucose-6-phosphate dehydrogenase -
LZT29_RS21060 (LZT29_04368) 185089..185784 + 696 WP_054633989.1 ROK family protein -
LZT29_RS21065 (LZT29_04369) 185944..186243 - 300 WP_054633990.1 CcdB family protein Toxin
LZT29_RS21070 (LZT29_04370) 186246..186464 - 219 WP_006121899.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
LZT29_RS21075 (LZT29_04371) 186977..187237 + 261 WP_054633991.1 hypothetical protein -
LZT29_RS21080 (LZT29_04372) 187438..187770 - 333 WP_253274974.1 ATP-binding protein -
LZT29_RS21085 (LZT29_04373) 188078..189415 - 1338 WP_054633993.1 pyrimidine utilization transport protein G -
LZT29_RS21090 (LZT29_04374) 189447..189989 - 543 WP_039339420.1 pyrimidine utilization flavin reductase protein F -
LZT29_RS21095 (LZT29_04375) 190019..190609 - 591 WP_283789002.1 malonic semialdehyde reductase -
LZT29_RS21100 (LZT29_04376) 190594..191433 - 840 WP_283789004.1 pyrimidine utilization protein D -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - fliC 1..262265 262265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-98)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11008.69 Da        Isoelectric Point: 7.0045

>T268573 WP_054633990.1 NZ_CP116286:c186243-185944 [Pantoea stewartii]
MQFDVYSHKNGKKYPYLVEIQSYLIDTPGRLMVAPLALSGEFVGSGELYPEVLVNGSKYRVVTTDIASVPVKALGDKVGD
VSQYEATIKNAIFRLFWGF

Download         Length: 300 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8516.56 Da        Isoelectric Point: 5.1504

>AT268573 WP_006121899.1 NZ_CP116286:c186464-186246 [Pantoea stewartii]
MKYRTNVTIDKEAYEIFSSAGLNLSKMVNELVTTEARRIRAERWKEENRESMKAFSDFVGEEGSLSDMYRNW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB H3RK39

References