Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 185944..186464 Replicon plasmid pPSbnut
Accession NZ_CP116286
Organism MAG: Pantoea stewartii isolate RON18713

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag LZT29_RS21065 Protein ID WP_054633990.1
Coordinates 185944..186243 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID H3RK39
Locus tag LZT29_RS21070 Protein ID WP_006121899.1
Coordinates 186246..186464 (-) Length 73 a.a.

Genomic Context

LZT29_RS21050LZT29_RS21055LZT29_RS21060LZT29_RS21075LZT29_RS21065LZT29_RS21070LZT29_RS21080LZT29_RS21085LZT29_RS21090LZT29_RS21095LZT29_RS21100
Location: 182679..183683 (1005 bp)
Type: Others
Protein ID: WP_054633987.1
Location: 183701..185071 (1371 bp)
Type: Others
Protein ID: WP_283788997.1
Location: 185089..185784 (696 bp)
Type: Others
Protein ID: WP_054633989.1
Location: 186977..187237 (261 bp)
Type: Others
Protein ID: WP_054633991.1
Location: 185944..186243 (300 bp)
Type: Toxin
Protein ID: WP_054633990.1
Location: 186246..186464 (219 bp)
Type: Antitoxin
Protein ID: WP_006121899.1
Location: 187438..187770 (333 bp)
Type: Others
Protein ID: WP_253274974.1
Location: 188078..189415 (1338 bp)
Type: Others
Protein ID: WP_054633993.1
Location: 189447..189989 (543 bp)
Type: Others
Protein ID: WP_039339420.1
Location: 190019..190609 (591 bp)
Type: Others
Protein ID: WP_283789002.1
Location: 190594..191433 (840 bp)
Type: Others
Protein ID: WP_283789004.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
LZT29_RS21050 (LZT29_04366)182679..183683+1005WP_054633987.1decarboxylating 6-phosphogluconate dehydrogenase-
LZT29_RS21055 (LZT29_04367)183701..185071+1371WP_283788997.1glucose-6-phosphate dehydrogenase-
LZT29_RS21060 (LZT29_04368)185089..185784+696WP_054633989.1ROK family protein-
LZT29_RS21065 (LZT29_04369)185944..186243-300WP_054633990.1CcdB family proteinToxin
LZT29_RS21070 (LZT29_04370)186246..186464-219WP_006121899.1type II toxin-antitoxin system CcdA family antitoxinAntitoxin
LZT29_RS21075 (LZT29_04371)186977..187237+261WP_054633991.1hypothetical protein-
LZT29_RS21080 (LZT29_04372)187438..187770-333WP_253274974.1ATP-binding protein-
LZT29_RS21085 (LZT29_04373)188078..189415-1338WP_054633993.1pyrimidine utilization transport protein G-
LZT29_RS21090 (LZT29_04374)189447..189989-543WP_039339420.1pyrimidine utilization flavin reductase protein F-
LZT29_RS21095 (LZT29_04375)190019..190609-591WP_283789002.1malonic semialdehyde reductase-
LZT29_RS21100 (LZT29_04376)190594..191433-840WP_283789004.1pyrimidine utilization protein D-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
-insideNon-Mobilizable plasmid-fliC1..262265262265


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-98)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11008.69 Da        Isoelectric Point: 7.0045

>T268573 WP_054633990.1 NZ_CP116286:c186243-185944 [Pantoea stewartii]
MQFDVYSHKNGKKYPYLVEIQSYLIDTPGRLMVAPLALSGEFVGSGELYPEVLVNGSKYRVVTTDIASVPVKALGDKVGD
VSQYEATIKNAIFRLFWGF

Download         Length: 300 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8516.56 Da        Isoelectric Point: 5.1504

>AT268573 WP_006121899.1 NZ_CP116286:c186464-186246 [Pantoea stewartii]
MKYRTNVTIDKEAYEIFSSAGLNLSKMVNELVTTEARRIRAERWKEENRESMKAFSDFVGEEGSLSDMYRNW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
AlphaFold DBH3RK39

References