Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 175..694 Replicon plasmid pASal1_J228
Accession NZ_CP116264
Organism Aeromonas salmonicida subsp. salmonicida strain J228

Toxin (Protein)


Gene name relE Uniprot ID Q7X2F1
Locus tag PI861_RS22275 Protein ID WP_005321942.1
Coordinates 175..462 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q8GMP0
Locus tag PI861_RS22280 Protein ID WP_011069626.1
Coordinates 452..694 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PI861_RS22275 (PI861_22275) 175..462 - 288 WP_005321942.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PI861_RS22280 (PI861_22280) 452..694 - 243 WP_011069626.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PI861_RS22285 (PI861_22285) 726..1058 - 333 WP_005321955.1 hypothetical protein -
PI861_RS22290 (PI861_22290) 1175..1381 - 207 WP_129712442.1 hypothetical protein -
PI861_RS22295 (PI861_22295) 1383..1670 - 288 WP_005321949.1 hypothetical protein -
PI861_RS22300 (PI861_22300) 1770..2111 - 342 WP_011116720.1 hypothetical protein -
PI861_RS22305 (PI861_22305) 2112..2645 - 534 WP_011069625.1 hypothetical protein -
PI861_RS22310 (PI861_22310) 2683..3300 - 618 Protein_7 relaxase/mobilization nuclease domain-containing protein -
PI861_RS22315 (PI861_22315) 3350..3760 - 411 WP_011116719.1 MobC family plasmid mobilization relaxosome protein -
PI861_RS22320 (PI861_22320) 4433..5440 - 1008 WP_005321944.1 replication initiation protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..5468 5468


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(2-61)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11356.17 Da        Isoelectric Point: 9.9149

>T268570 WP_005321942.1 NZ_CP116264:c462-175 [Aeromonas salmonicida subsp. salmonicida]
MTFELEFDPRAWKEWKKLGDTVRQQFKKKLAEVLERPRVEANRLHGLPDCYKIKLRGAGYRLVYQVQDDRVLVFVVAVGK
REREQVYLDAGYRLE

Download         Length: 288 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9127.47 Da        Isoelectric Point: 4.6151

>AT268570 WP_011069626.1 NZ_CP116264:c694-452 [Aeromonas salmonicida subsp. salmonicida]
MGTINLRIDDELKTRSYAVLERLGVTPSELLRQTLEYVASQERLPFRTTVVTEDEEALLVLVRERLASPQKGIRVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151KDX2

Antitoxin

Source ID Structure
AlphaFold DB Q8GMP0

References