Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2232..2751 Replicon plasmid pASal1_J225
Accession NZ_CP116260
Organism Aeromonas salmonicida subsp. salmonicida strain J225

Toxin (Protein)


Gene name relE Uniprot ID Q7X2F1
Locus tag PI860_RS23210 Protein ID WP_005321942.1
Coordinates 2232..2519 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID Q8GMP0
Locus tag PI860_RS23215 Protein ID WP_011069626.1
Coordinates 2509..2751 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
PI860_RS23200 (PI860_23215) 1..5449 - 5449 WP_011116719.1 MobC family plasmid mobilization relaxosome protein -
PI860_RS23205 (PI860_23220) 1041..2048 - 1008 WP_005321944.1 replication initiation protein -
PI860_RS23210 (PI860_23225) 2232..2519 - 288 WP_005321942.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
PI860_RS23215 (PI860_23230) 2509..2751 - 243 WP_011069626.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
PI860_RS23220 (PI860_23235) 2783..3115 - 333 WP_005321955.1 hypothetical protein -
PI860_RS23225 (PI860_23240) 3232..3438 - 207 WP_129712442.1 hypothetical protein -
PI860_RS23230 (PI860_23245) 3440..3727 - 288 WP_005321949.1 hypothetical protein -
PI860_RS23235 (PI860_23250) 3827..4168 - 342 WP_011116720.1 hypothetical protein -
PI860_RS23240 (PI860_23255) 4169..4702 - 534 WP_011069625.1 hypothetical protein -
PI860_RS23245 (PI860_23260) 4740..5357 - 618 Protein_9 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..5449 5449


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-85)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(2-61)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11356.17 Da        Isoelectric Point: 9.9149

>T268568 WP_005321942.1 NZ_CP116260:c2519-2232 [Aeromonas salmonicida subsp. salmonicida]
MTFELEFDPRAWKEWKKLGDTVRQQFKKKLAEVLERPRVEANRLHGLPDCYKIKLRGAGYRLVYQVQDDRVLVFVVAVGK
REREQVYLDAGYRLE

Download         Length: 288 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9127.47 Da        Isoelectric Point: 4.6151

>AT268568 WP_011069626.1 NZ_CP116260:c2751-2509 [Aeromonas salmonicida subsp. salmonicida]
MGTINLRIDDELKTRSYAVLERLGVTPSELLRQTLEYVASQERLPFRTTVVTEDEEALLVLVRERLASPQKGIRVSLDDL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A151KDX2

Antitoxin

Source ID Structure
AlphaFold DB Q8GMP0

References