Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) yeeV-yafW/CbtA-CbeA
Location 4422953..4423746 Replicon chromosome
Accession NZ_CP116249
Organism Enterobacter roggenkampii strain 120063

Toxin (Protein)


Gene name yeeV Uniprot ID S1EZ92
Locus tag KK030_RS21920 Protein ID WP_000854726.1
Coordinates 4423369..4423746 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name yafW Uniprot ID S1EBQ7
Locus tag KK030_RS21915 Protein ID WP_001548930.1
Coordinates 4422953..4423279 (+) Length 109 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KK030_RS21865 (KK030_21820) 4418257..4419078 + 822 WP_214575091.1 DUF932 domain-containing protein -
KK030_RS21870 (KK030_21825) 4419296..4419997 + 702 WP_008324530.1 WYL domain-containing protein -
KK030_RS21875 (KK030_21830) 4420044..4420280 + 237 WP_001115854.1 protein YpjK -
KK030_RS21880 (KK030_21835) 4420280..4420723 + 444 WP_053263801.1 lipoprotein YafY -
KK030_RS21885 (KK030_21840) 4420746..4421213 + 468 WP_023305531.1 protein YkfB -
KK030_RS21890 (KK030_21845) 4421290..4421544 + 255 WP_101743273.1 DUF905 domain-containing protein -
KK030_RS21895 (KK030_21850) 4421534..4421656 + 123 WP_077760868.1 DUF905 family protein -
KK030_RS21900 (KK030_21855) 4421754..4422212 + 459 WP_000211838.1 antirestriction protein -
KK030_RS21905 (KK030_21860) 4422228..4422704 + 477 WP_001549015.1 RadC family protein -
KK030_RS21910 (KK030_21865) 4422713..4422934 + 222 WP_016239820.1 DUF987 domain-containing protein -
KK030_RS21915 (KK030_21870) 4422953..4423279 + 327 WP_001548930.1 type IV toxin-antitoxin system antitoxin YafW Antitoxin
KK030_RS21920 (KK030_21875) 4423369..4423746 + 378 WP_000854726.1 TA system toxin CbtA family protein Toxin
KK030_RS21925 (KK030_21880) 4423743..4424231 + 489 WP_001547769.1 DUF5983 family protein -
KK030_RS21930 (KK030_21885) 4424243..4424440 + 198 WP_000839269.1 DUF957 domain-containing protein -
KK030_RS21935 (KK030_21890) 4424525..4425367 + 843 WP_001548928.1 DUF4942 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(1-112)

Antitoxin

Antitoxin CbeA

(6-103)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 14164.10 Da        Isoelectric Point: 7.8045

>T268562 WP_000854726.1 NZ_CP116249:4423369-4423746 [Enterobacter roggenkampii]
MKTLPDTHVREASRCPSPVTIWQTLLSRLLDQHYGLTLNDTPFADERVIEQHIEAGISLCDAVNFLVEKYALVRTDQPGF
SACTRSQLINSIDILRARRATGLMTRDNYRTVNNITQGKHPEAKQ

Download         Length: 378 bp

Antitoxin


Download         Length: 109 a.a.        Molecular weight: 12301.97 Da        Isoelectric Point: 7.0273

>AT268562 WP_001548930.1 NZ_CP116249:4422953-4423279 [Enterobacter roggenkampii]
MSNPTRGLQREITLRLGARLVQEGNRLHYLADRASITGKFSDIECRKLDETFPHFIRQMESMLTTGELSPHHAHCVTLYH
NDLTCEADTFGSCGYVYLAVYPTPETKK

Download         Length: 327 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1EZ92

Antitoxin

Source ID Structure
AlphaFold DB S1EBQ7

References