Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4217663..4218239 Replicon chromosome
Accession NZ_CP116249
Organism Enterobacter roggenkampii strain 120063

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag KK030_RS20885 Protein ID WP_214574428.1
Coordinates 4217952..4218239 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID A0A156JBA1
Locus tag KK030_RS20880 Protein ID WP_023293359.1
Coordinates 4217663..4217965 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KK030_RS20855 (KK030_20810) 4213770..4214315 + 546 WP_008501313.1 YfaZ family outer membrane protein -
KK030_RS20860 (KK030_20815) 4214315..4214635 + 321 WP_008501314.1 hypothetical protein -
KK030_RS20865 (KK030_20820) 4214681..4216051 - 1371 WP_214574432.1 NAD-dependent succinate-semialdehyde dehydrogenase -
KK030_RS20870 (KK030_20825) 4216203..4216946 + 744 WP_129343673.1 AraC family transcriptional regulator -
KK030_RS20875 (KK030_20830) 4216994..4217632 + 639 WP_214574430.1 LysE family translocator -
KK030_RS20880 (KK030_20835) 4217663..4217965 - 303 WP_023293359.1 BrnA antitoxin family protein Antitoxin
KK030_RS20885 (KK030_20840) 4217952..4218239 - 288 WP_214574428.1 BrnT family toxin Toxin
KK030_RS20890 (KK030_20845) 4218394..4219665 + 1272 WP_045353153.1 DUF445 domain-containing protein -
KK030_RS20895 (KK030_20850) 4219662..4220738 - 1077 WP_055321639.1 DUF2955 domain-containing protein -
KK030_RS20900 (KK030_20855) 4220728..4221795 - 1068 WP_139963628.1 HlyD family secretion protein -
KK030_RS20905 (KK030_20860) 4221792..4222262 - 471 WP_008501325.1 MarR family transcriptional regulator -
KK030_RS20910 (KK030_20865) 4222408..4223103 - 696 WP_214574426.1 winged helix-turn-helix domain-containing protein -
KK030_RS20915 (KK030_20870) 4223096..4223212 - 117 Protein_4091 amino acid-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(37-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11291.85 Da        Isoelectric Point: 9.4591

>T268561 WP_214574428.1 NZ_CP116249:c4218239-4217952 [Enterobacter roggenkampii]
MPMEYEWDNNKAKSNLQKHGIRFEDAVMVFDDPYHLSVQDRYENGKFRWQTIGLVQGLLVILVAHTVRFESGGEIIRIIS
ARKADRKERSRYEHR

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11369.01 Da        Isoelectric Point: 10.2483

>AT268561 WP_023293359.1 NZ_CP116249:c4217965-4217663 [Enterobacter roggenkampii]
MSIVKHKRGSAPEVSARRVAELKALAEKPDAEIDYSDIPATDDEQWSGAVRGKFYRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMLRDQNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A156JBA1

References