Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3686130..3686750 Replicon chromosome
Accession NZ_CP116249
Organism Enterobacter roggenkampii strain 120063

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag KK030_RS18390 Protein ID WP_008499287.1
Coordinates 3686532..3686750 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag KK030_RS18385 Protein ID WP_008499288.1
Coordinates 3686130..3686504 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KK030_RS18375 (KK030_18340) 3681274..3684420 + 3147 WP_008499289.1 multidrug efflux RND transporter permease subunit AcrB -
KK030_RS18380 (KK030_18345) 3684687..3685667 + 981 WP_271775139.1 IS5-like element ISKpn26 family transposase -
KK030_RS18385 (KK030_18350) 3686130..3686504 + 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
KK030_RS18390 (KK030_18355) 3686532..3686750 + 219 WP_008499287.1 HHA domain-containing protein Toxin
KK030_RS18395 (KK030_18360) 3686957..3687508 + 552 WP_214573598.1 maltose O-acetyltransferase -
KK030_RS18400 (KK030_18365) 3687626..3688093 + 468 WP_008499285.1 YlaC family protein -
KK030_RS18405 (KK030_18370) 3688065..3689525 - 1461 WP_059359545.1 PLP-dependent aminotransferase family protein -
KK030_RS18410 (KK030_18375) 3689627..3690337 + 711 WP_045352701.1 GNAT family protein -
KK030_RS18415 (KK030_18380) 3690334..3690474 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
KK030_RS18420 (KK030_18385) 3690477..3690737 - 261 WP_006176933.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3684687..3685667 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T268559 WP_008499287.1 NZ_CP116249:3686532-3686750 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT268559 WP_008499288.1 NZ_CP116249:3686130-3686504 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References