Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) kacAT/DUF1778(antitoxin)
Location 3006638..3007435 Replicon chromosome
Accession NZ_CP116249
Organism Enterobacter roggenkampii strain 120063

Toxin (Protein)


Gene name KacT Uniprot ID -
Locus tag KK030_RS14985 Protein ID WP_214574848.1
Coordinates 3006638..3007159 (-) Length 174 a.a.

Antitoxin (Protein)


Gene name KacA Uniprot ID W7PG43
Locus tag KK030_RS14990 Protein ID WP_008499829.1
Coordinates 3007166..3007435 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KK030_RS14955 (KK030_14925) 3002221..3002910 + 690 WP_214574849.1 pyrimidine utilization protein B -
KK030_RS14960 (KK030_14930) 3002922..3003308 + 387 WP_008499822.1 pyrimidine utilization protein C -
KK030_RS14965 (KK030_14935) 3003316..3004116 + 801 WP_021240807.1 pyrimidine utilization protein D -
KK030_RS14970 (KK030_14940) 3004126..3004716 + 591 WP_032651257.1 malonic semialdehyde reductase -
KK030_RS14975 (KK030_14945) 3004726..3005220 + 495 WP_023292823.1 pyrimidine utilization flavin reductase protein F -
KK030_RS14980 (KK030_14950) 3005242..3006564 + 1323 WP_008499826.1 pyrimidine utilization transport protein G -
KK030_RS14985 (KK030_14955) 3006638..3007159 - 522 WP_214574848.1 GNAT family N-acetyltransferase Toxin
KK030_RS14990 (KK030_14960) 3007166..3007435 - 270 WP_008499829.1 DUF1778 domain-containing protein Antitoxin
KK030_RS14995 (KK030_14965) 3007497..3008414 - 918 WP_025912980.1 DMT family transporter -
KK030_RS15000 (KK030_14970) 3008533..3008703 - 171 WP_013097201.1 general stress protein -
KK030_RS15005 (KK030_14975) 3009095..3009691 + 597 WP_008499831.1 NAD(P)H:quinone oxidoreductase -
KK030_RS15010 (KK030_14980) 3009712..3009939 + 228 WP_008499832.1 YccJ family protein -
KK030_RS15015 (KK030_14985) 3010035..3010712 - 678 Protein_2940 contractile injection system protein, VgrG/Pvc8 family -
KK030_RS15025 (KK030_14995) 3011515..3012336 + 822 Protein_2942 magnesium transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 174 a.a.        Molecular weight: 19684.43 Da        Isoelectric Point: 7.0497

>T268558 WP_214574848.1 NZ_CP116249:c3007159-3006638 [Enterobacter roggenkampii]
VDNLTIEMFSEGKDYDFRDFDCGEPSLNVFLTEHLVRQHNGRILRGYLLKDRDGPRVLGYYTLSGSCFEKAMLPSKTQQR
RIPYSNVPSVALGRLAIHKDLQGLEWGTTLVTHAMRVVYLASQAVGVHGIFVDALNDQAKQFYLKQGFIPLTDENSHSLF
FPTKSIERLFEQA

Download         Length: 522 bp

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10262.72 Da        Isoelectric Point: 5.8836

>AT268558 WP_008499829.1 NZ_CP116249:c3007435-3007166 [Enterobacter roggenkampii]
MPALKKQRIDLRLTDEDKTMIEEAAAMTNQTITQFMVNSASERAAEVIEQHRRLVLNEASWNAVMDAIDNPPEPNERLKR
AAKRLRNME

Download         Length: 270 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB W7PG43

References