Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1713776..1714366 Replicon chromosome
Accession NZ_CP116249
Organism Enterobacter roggenkampii strain 120063

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag KK030_RS08415 Protein ID WP_094943135.1
Coordinates 1714034..1714366 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID -
Locus tag KK030_RS08410 Protein ID WP_094919038.1
Coordinates 1713776..1714033 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KK030_RS08395 (KK030_08385) 1709360..1709746 + 387 Protein_1632 MBL fold metallo-hydrolase -
KK030_RS08400 (KK030_08390) 1709817..1710514 + 698 Protein_1633 IS1 family transposase -
KK030_RS08405 (KK030_08395) 1710525..1713104 - 2580 WP_250902612.1 hypothetical protein -
KK030_RS08410 (KK030_08400) 1713776..1714033 + 258 WP_094919038.1 antitoxin Antitoxin
KK030_RS08415 (KK030_08405) 1714034..1714366 + 333 WP_094943135.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
KK030_RS08425 (KK030_08415) 1714661..1716850 - 2190 WP_008499481.1 TonB-dependent siderophore receptor -
KK030_RS08430 (KK030_08420) 1716877..1718202 - 1326 WP_032675143.1 SidA/IucD/PvdA family monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 1699137..1714366 15229


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(2-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11816.70 Da        Isoelectric Point: 10.2965

>T268552 WP_094943135.1 NZ_CP116249:1714034-1714366 [Enterobacter roggenkampii]
MERGEIWLVSLDPSAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEGAGTKTMGVIRCDQPRTI
DMAARNGMRLERIPDAVVNEVLARLDAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9422.88 Da        Isoelectric Point: 4.4607

>AT268552 WP_094919038.1 NZ_CP116249:1713776-1714033 [Enterobacter roggenkampii]
MYTTRLKKVGGSIMLAVPPAVLKTLELSTDSEVGMTINNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKELL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References