Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) ypjF-yeeU/CbtA-CbeA
Location 1017890..1018623 Replicon chromosome
Accession NZ_CP116249
Organism Enterobacter roggenkampii strain 120063

Toxin (Protein)


Gene name ypjF Uniprot ID -
Locus tag KK030_RS05010 Protein ID WP_078309458.1
Coordinates 1017890..1018219 (-) Length 110 a.a.

Antitoxin (Protein)


Gene name yeeU Uniprot ID -
Locus tag KK030_RS05015 Protein ID WP_078309456.1
Coordinates 1018258..1018623 (-) Length 122 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KK030_RS04990 (KK030_04985) 1013852..1014457 + 606 WP_008502560.1 ankyrin repeat domain-containing protein -
KK030_RS04995 (KK030_04990) 1014606..1015586 - 981 WP_271798840.1 IS5-like element ISKpn26 family transposase -
KK030_RS05000 (KK030_04995) 1015739..1016515 + 777 WP_111967713.1 isocitrate lyase/phosphoenolpyruvate mutase family protein -
KK030_RS05005 (KK030_05000) 1016499..1017545 + 1047 WP_214574530.1 methylated-DNA--[protein]-cysteine S-methyltransferase -
KK030_RS05010 (KK030_05005) 1017890..1018219 - 330 WP_078309458.1 TA system toxin CbtA family protein Toxin
KK030_RS05015 (KK030_05010) 1018258..1018623 - 366 WP_078309456.1 type IV toxin-antitoxin system YeeU family antitoxin Antitoxin
KK030_RS05020 (KK030_05015) 1018649..1018832 - 184 Protein_973 DUF987 family protein -
KK030_RS05025 (KK030_05020) 1018829..1019371 - 543 WP_214574529.1 DNA repair protein RadC -
KK030_RS05030 (KK030_05025) 1019384..1019827 - 444 WP_078309452.1 antirestriction protein -
KK030_RS05035 (KK030_05030) 1019858..1020679 - 822 WP_078309451.1 DUF932 domain-containing protein -
KK030_RS05040 (KK030_05035) 1020771..1021112 - 342 WP_078309449.1 hypothetical protein -
KK030_RS05045 (KK030_05040) 1021147..1021611 - 465 WP_078309448.1 hypothetical protein -
KK030_RS05050 (KK030_05045) 1021737..1021895 - 159 WP_101706469.1 hypothetical protein -
KK030_RS05055 (KK030_05050) 1022108..1022995 - 888 WP_078309444.1 50S ribosome-binding GTPase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1003418..1021895 18477
- flank IS/Tn - - 1014606..1015586 980


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

CbtA toxin of type IV toxin-antitoxin system

(2-107)

Antitoxin

Antitoxin CbeA

(17-117)


Sequences

Toxin        


Download         Length: 110 a.a.        Molecular weight: 12303.17 Da        Isoelectric Point: 8.5043

>T268551 WP_078309458.1 NZ_CP116249:c1018219-1017890 [Enterobacter roggenkampii]
MQIISSAPTRAAPLSLSPVEIWQRLLTHLLSQHYGLTLNDTPFSYETTIREHIDAGVSLSDAVNFLVEKYGLVRIDRKGF
SWQEQTPYISVVDILMARRSTGLLKTTVK

Download         Length: 330 bp

Antitoxin


Download         Length: 122 a.a.        Molecular weight: 13427.12 Da        Isoelectric Point: 5.4451

>AT268551 WP_078309456.1 NZ_CP116249:c1018623-1018258 [Enterobacter roggenkampii]
MNNHSESGTRPENSAIQQWGLKRAITPCFGARLVQEGNRLHYLADRAGFSGAFTDDVAMHLDQAFPLMMKQLELMLTSGE
LNPSHPHCVTLYHNGLTCEADTLGSCGYVYIAIYPEQTEPQ

Download         Length: 366 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References