Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 817889..818546 Replicon chromosome
Accession NZ_CP116249
Organism Enterobacter roggenkampii strain 120063

Toxin (Protein)


Gene name cptA Uniprot ID A0A1H8U0Q4
Locus tag KK030_RS04030 Protein ID WP_021242050.1
Coordinates 818136..818546 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W7NX65
Locus tag KK030_RS04025 Protein ID WP_006178375.1
Coordinates 817889..818155 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
KK030_RS04005 (KK030_04000) 813323..814756 - 1434 WP_023294510.1 6-phospho-beta-glucosidase BglA -
KK030_RS04010 (KK030_04005) 814873..815604 - 732 WP_008499714.1 MurR/RpiR family transcriptional regulator -
KK030_RS04015 (KK030_04010) 815870..816529 + 660 WP_021242052.1 hemolysin III family protein -
KK030_RS04020 (KK030_04015) 816614..817594 - 981 WP_214574742.1 tRNA-modifying protein YgfZ -
KK030_RS04025 (KK030_04020) 817889..818155 + 267 WP_006178375.1 FAD assembly factor SdhE Antitoxin
KK030_RS04030 (KK030_04025) 818136..818546 + 411 WP_021242050.1 protein YgfX Toxin
KK030_RS04035 (KK030_04030) 818553..819074 - 522 WP_008499710.1 flavodoxin FldB -
KK030_RS04040 (KK030_04035) 819176..820072 + 897 WP_214574741.1 site-specific tyrosine recombinase XerD -
KK030_RS04045 (KK030_04040) 820101..820814 + 714 WP_214574740.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
KK030_RS04050 (KK030_04045) 820820..822553 + 1734 WP_214574739.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16097.08 Da        Isoelectric Point: 10.9468

>T268550 WP_021242050.1 NZ_CP116249:818136-818546 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1340

>AT268550 WP_006178375.1 NZ_CP116249:817889-818155 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8U0Q4

Antitoxin

Source ID Structure
AlphaFold DB W7NX65

References